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Lauren N. Spezia Adachi,Rafael Vercelino,Carla de Oliveira,Vanessa L. Scarabelot,Andressa de Souza,Liciane F. Medeiros,Stefania G. Cioato,Wolnei Caumo,Iraci L.S. Torres 사단법인약침학회 2018 Journal of Acupuncture & Meridian Studies Vol.11 No.3
The present study aimed to determine whether isoflurane interferes with the analgesiceffects of acupuncture (Ac) and electroacupuncture (EA), using a neuropathic pain(NP) rat model. In total, 140 male Wistar rats were used; isoflurane-induced nociceptiveresponse was evaluated using the von Frey test, serum calcium-binding protein b (S100b)levels and nerve growth factor (NGF) levels in the left sciatic nerve. The NP model wasinduced by chronic constriction injury of the sciatic nerve at 14 days after surgery. Treatment was initiated after NP induction with or without isoflurane anesthesia (20 min/day/8 days). The von Frey test was performed at baseline, 14 days postoperatively, andimmediately, 24 h, and 48 h after the last treatment. Results of the nociceptive test andthree-way analysis of variance were analyzed by generalized estimating equations, theBonferroni test, followed by StudenteNewmaneKeuls or Fisher’s least significant differencetests for comparing biochemical parameters (significance defined as p 0.05). Atbaseline, no difference was noted in the nociceptive response threshold among allgroups. Fourteen days after surgery, compared with other groups, NP groups showed adecreased pain threshold, confirming establishment of NP. Ac and EA enhanced the mechanicalpain threshold immediately after the last session in the NP groups, without anesthesia. Isoflurane administration caused increased nociceptive threshold in all groups,and this effect persisted for 48 h after the last treatment. There was an interaction betweenthe independent variables: pain, treatments, and anesthesia in serum S100b levelsand NGF levels in the left sciatic nerve. Isoflurane enhanced the analgesic effects of Acand EA and altered serum S100b and left sciatic nerve NGF levels in rats with NP.