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RISS 인기검색어
- 검색키워드
- 저자 : Vandamme, Drieke (검색결과 2 건)
- 무료
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- 유료
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Robustness and Evolvability of the Human Signaling Network
Kim, Junil,Vandamme, Drieke,Kim, Jeong-Rae,Munoz, Amaya Garcia,Kolch, Walter,Cho, Kwang-Hyun Public Library of Science 2014 PLoS computational biology Vol.10 No.7
<▼1><P>Biological systems are known to be both robust and evolvable to internal and external perturbations, but what causes these apparently contradictory properties? We used Boolean network modeling and attractor landscape analysis to investigate the evolvability and robustness of the human signaling network. Our results show that the human signaling network can be divided into an evolvable core where perturbations change the attractor landscape in state space, and a robust neighbor where perturbations have no effect on the attractor landscape. Using chemical inhibition and overexpression of nodes, we validated that perturbations affect the evolvable core more strongly than the robust neighbor. We also found that the evolvable core has a distinct network structure, which is enriched in feedback loops, and features a higher degree of scale-freeness and longer path lengths connecting the nodes. In addition, the genes with high evolvability scores are associated with evolvability-related properties such as rapid evolvability, low species broadness, and immunity whereas the genes with high robustness scores are associated with robustness-related properties such as slow evolvability, high species broadness, and oncogenes. Intriguingly, US Food and Drug Administration-approved drug targets have high evolvability scores whereas experimental drug targets have high robustness scores.</P></▼1><▼2><P><B>Author Summary</B></P><P>Biological systems are known to be robust and evolvable to internal mutations and external environmental changes. What causes these apparently contradictory properties? This study shows that the human signaling network can be decomposed into two structurally distinct subgroups of links that provide both evolvability to environmental changes and robustness against internal mutations. The decomposition of the human signaling network reveals an evolutionary design principle of the network, and also facilitates the identification of potential drug targets.</P></▼2>
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Won, Young Suk,Vandamme, Peter,Yoon, Jung Hoon,Park, Yong Ho,Hyun, Byung Hwa,Kim, Hyoung Chin,Itoh, Toshio,Tanioka, Yoshikuni,Choi, Yang Kyu Oxford University Press 2007 FEMS microbiology letters Vol.271 No.2
<P>A slowly growing microaerophilic Helicobacter species was isolated from the feces of the common marmoset (Callithrix jacchus). This bacterium possessed a pair of nonsheathed bipolar flagella, was positive for oxidase, catalase and alkaline phosphatase activities, but was negative for gamma-glutamyltranspeptidase and urease activity and for nitrate reduction. The bacterium was susceptible to nalidixic acid and resistant to cephalotine and did not hydrolyze hippurate. On the basis of phenotypic characteristics, 16S rRNA gene sequence analysis and whole-cell protein profiles, the isolate represents a new species of the genus Helicobacter, for which the name Helicobacter callitrichis sp. nov. is proposed; the type strain of the new species is R-204(T) (GenBank accession number AY192526).</P>
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