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Farzaneh Dehghani,Reza Asadi-Golshan,Vahid Razban,Esmaeil Mirzaei,Abdolkarim Rahmanian,Sahar Khajeh,Zohreh Mostafavi-Pour 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.5
Study Design: Experimental animal study. Purpose: This study aimed to assess effects of conditioned medium (CM) of dental pulp-derived stem cells loaded in collagen hydrogel on functional recovery following spinal cord injury (SCI). Overview of Literature: SCI affects sensory and motor functions, and behavioral recovery is the most essential purpose of therapeutic intervention. Recent studies have reported that CM from dental pulp-derived stem cells has therapeutic benefits. In addition, collagen hydrogel acts as a drug delivery system in SCI experiments. Methods: Stem cells from human exfoliated deciduous teeth (SHEDs) were cultured, and SHED-CM was harvested and concentrated. Collagen hydrogel containing SHED-CM was prepared. The rats were divided into five groups receiving laminectomy, compressive SCI with or without intraspinal injection of biomaterials (SHED-CM), and collagen hydrogel with or without SHED-CM. Basso, Beattie, and Bresnahan (BBB) scoring, inclined plane, cold allodynia, and beam walk tests were performed for 6 weeks to assess locomotor, motor, sensory, and sensory-motor performances, respectively. Results: Scores of the rats receiving SHED-CM loaded in collagen hydrogel were significantly better than those of the other injured groups at 1-week post-injury for BBB, 2 weeks for inclined plane, 2 weeks for cold allodynia, and 4 weeks for beam walk tests (p <0.05). The differences remained significant throughout the study. Conclusions: Intraspinal administration of SHED-CM loaded in collagen hydrogel leads to improved functional recovery and proposes a cell-free therapeutic approach for SCI.
Samahe Sadjadi,Vahid Farzaneh,Samira Shirvani,Mohammad Ghashghaee 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.3
This article presents the effects of three copper precursors and four precipitating agents on the catalytic performance of the corresponding co-precipitated Cu-MgO catalysts in the vapor-phase hydrogenation of furfural. The chemical and physical properties were analyzed by means of XRD, BET, SEM, and EDX techniques. The nitrate precursor provided the highest performance (conversion of ~89%). Whereas, the catalyst prepared with NaOH was the most efficient (furfuryl alcohol yield of >90%) during 240min; the most durable conversion (~95%) was assured with Na2- CO3, and the highest selectivity to furfuryl alcohol (>97%) was achieved with K2CO3 as the precipitating agent. The least efficient catalyst (prepared with ammonium carbonate) led to 5-methylfurfural and 2,2-methylenebisfuran as the main byproducts. The major byproducts over the rest of the catalysts included tetrahydrofurfuryl alcohol, furfuryl ether, 1-pentanol, and 2-methylfuran. An increasing trend of furfuryl alcohol selectivity with time-on-stream was evident for all of the catalysts.