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Gene Therapy for Infections Diseases
Gene Therapy Research Unit, KRIBB 가톨릭 의과학연구원 1997 가톨릭 의과학연구원 국제학술대회 Vol.1 No.-
Immunologic effector functions mediated by Fc receptors have been either generated de novo in a hope to prevent or treat bacterial infections. Enhancement of phagocytic capacity, a major effector function of Fc receptors, has been achieved by modifications of Fc receptors. Phagocytic signaling mediated by Fc γ receptors is enhanced either by multiplying a portion of the cytoplasmic domin(ITAM) of Fc γ receptors of by substituting the xx sequences of the YxxL sequences in the ITAM. Introduction of the enhanced phagocytic function into non-phagocytic cells is employed. Various cell types including fibroblasts and epithelial cells exhibited phagocytosis of IgG coated res blood cells. These cells expressing Fc γ receptors are also able to kill efficiently internalized bacteria. We have constructed an adenoviral vector (Fcγ RIIA-Adl) that expresses Fcγ RIIA which mediates efficient phagocytosis. When infected by the recombinant adenovirus primary lung epithelial cells exhibited phagocytosis and killing activity of both IgG coated red blood cells and bacteria. Other cell types that are likely to be exposed to bacterial pathogens in nature have also been found to function similarly upon infection of the recombinant adenovirus. In guiea pigs infected with the Fcγ RIIA-Adl, immune-complex clearance has been found significantly enhanced for the ^51Cr loaded red blood cells in a transient manner Fc γ receptor mediated phagocytosis was also found to increase by 3 to 5 fold in transiently transfected cells when protin tyrosine kinase Syk is co-expressed. We are currently in the process of producing adenoviral vectors that express both the Fcγ receptor and the Syk kinase. This gene therapy approach could bd developed as new modes of preventing or treating acute bacterial infections.
Latiff, Latiffah A.,Rahman, Sabariah Abdul,Wee, Wong Yong,Dashti, Sareh,Asri, Andi Anggeriana Andi,Unit, Nor Hafeeza,Li, Shirliey Foo Siah,Esfehani, Ali Jafarzadeh,Ahmad, Salwana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: The participation of women in cervical cancer screening in Malaysia is low. Self-sampling might be able to overcome this problem. The aim of this study was to assess the reliability of self-sampling for cervical smear in our country. Materials and Methods: This cross-sectional study was conducted on 258 community dwelling women from urban and rural settings who participated in health campaigns. In order to reduce the sampling bias, half of the study population performed the self-sampling prior to the physician sampling while the other half performed the self-sampling after the physician sampling, randomly. Acquired samples were assessed for cytological changes as well as HPV DNA detection. Results: The mean age of the subjects was $40.4{\pm}11.3years$. The prevalence of abnormal cervical changes was 2.7%. High risk and low risk HPV genotypes were found in 4.0% and 2.7% of the subjects, respectively. A substantial agreement was observed between self-sampling and the physician obtained sampling in cytological diagnosis (k=0.62, 95%CI=0.50, 0.74), micro-organism detection (k=0.77, 95%CI=0.66, 0.88) and detection of hormonal status (k=0.75, 95%CI=0.65, 0.85) as well as detection of high risk (k=0.77, 95%CI=0.4, 0.98) and low risk (K=0.77, 95%CI=0.50, 0.92) HPV. Menopausal state was found to be related with 8.39 times more adequate cell specimens for cytology but 0.13 times less adequate cell specimens for virological assessment. Conclusions: This study revealed that self-sampling has a good agreement with physician sampling in detecting HPV genotypes. Self-sampling can serve as a tool in HPV screening while it may be useful in detecting cytological abnormalities in Malaysia.
United Nations Environment Programme, Environmental Effects Assessment Panel, United Nations Environment Programme, Environmental Effects Assessment Panel Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.1
After the enthusiastic celebration of the $20^{th}$ Anniversary of the Montreal Protocol on Substances that Deplete the Ozone Layer in 2007, the work for the protection of the ozone layer continues. The Environmental Effects Assessment Panel is one of the three expert panels within the Montreal Protocol. This "EEAP" deals with the increase of the UV irradiance on the Earth's surface and its effects on human health, animals, plants, biogeochemistry, air quality and materials. For the past few years, interactions of ozone depletion with climate change have also been considered. It has become clear that the environmental problems will be long-lasting. In spite of the fact that the worldwide production of ozone depleting chemicals has already been reduced by 95%, the environmental disturbances are expected to persist for about the next half a century, even if the protective work is actively continued, and completed. The latest full report was published in Photochem. Photobiol. Sci., 2007, 6, 201-332, and the last progress report in Photochem. Photobiol. Sci., 2008, 7, 15-27. The next full report on environmental effects is scheduled for the year 2010. The present progress report 2008 is one of the short interim reports, appearing annually.