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RISS 인기검색어
- 검색키워드
- 저자 : Tsuyoshi Shiina (검색결과 2 건)
- 무료
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Development and clinical translation of photoacoustic mammography
Tsuyoshi Shiina,Masakazu Toi,Takayuki Yagi 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.2
To practically apply photoacoustic (PA) imaging technology in medicine, we have developed prototypes of a photoacousticmammography (PAM) device to acquire images for diagnosing breast cancer in the Kyoto University/Canon joint researchproject (CK project supported by MEXT, Japan). First, the basic ability of the PAM system to visualize the network ofblood vessels and the Hb saturation index was evaluated using a prototype of PAM that has a flat scanning detector and iscapable of simultaneously acquiring photoacoustic (PA) and ultrasound images. Next, another prototype of a PAM devicewith hemispherical sensors was developed to improve the visibility of the 3D structure of vessels by reducing the limitedview effect. In clinical examination of breast cancer cases, the PAM system allowed 3D visualization of fine vesselnetworks with a spatial resolution of a half-millimeter and enabled us to determine the features of tumor-related vascularstructures in human breast cancer. In addition, the oxygen saturation status of Hb was visualized using two differentwavelengths, enabling more precise characterization of the tumor microenvironment. Results of clinical evaluation usingour developed prototype of a PAM device confirmed that PA imaging technology has the potential to promote earlydetection of breast cancer, and realization of its practical use is expected in the near future.
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An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia
Akihiro Shiina,Nobuhisa Kanahara,Tsuyoshi Sasaki,Yasunori Oda,Tasuku Hashimoto,Tadashi Hasegawa,Taisuke Yoshida,Masaomi Iyo,갠지하시모토 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.1
Objective: Schizophrenia is a mental disorder characterized by severe cognitive impairment. Accumulating evidence suggests a role for oxidative stress in the pathophysiology of schizophrenia. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. In this study, we attempted to evaluate the effect of SFN on cognitive impairment in medicated patients with schizophrenia. Methods: We recruited a total of 10 outpatients with schizophrenia, all of whom gave informed consent. Participants took 3 tablets of SFN, consisting of 30 mg of SFN-glucosinolate per day, for 8 weeks. Clinical symptoms using the Positive and Negative Syndrome Scale (PANSS) and cognitive function using the Japanese version of CogState battery were evaluated at the beginning of the study and at week 8. Results: A total of 7 patients completed the trial. The mean score in the Accuracy component of the One Card Learning Task increased significantly after the trial. However, we detected no other significant changes in participants. Conclusion: This result suggests that SFN has the potential to improve cognitive function in patients with schizophrenia.
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