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Triterpenoids from Dysoxylum genus and their biological activities
Al Arofatus Naini,Tri Mayant,Unang Supratman 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.2
This study aims to analyze the ethnobotanical,chemical, and biological activities of triterpenoid compoundsisolated from the Dysoxylum genus of the Meliaceaefamily between 1974 and 2021. The species are mainly distributedin Africa, Asia, and Australia, and used as a traditionalmedicine to treat various diseases. Triterpenoid wasfi rst isolated in 1976 and as tetranortriterpenoid or limonoid,it was named dysobinin. Several studies were conducted formore than 40 years on the plants’ stems, bark, and leaves,where approximately 279 triterpenoid compounds fromseveral groups such as dammarane, nortriterpenoid, oleanane,lupane, tirucallane, cyclolanostane, or cycloartane,glabretal, and cycloapoeuphane-types were isolated withsome synthetic products. In addition, the hypothetical routeof triterpenes biosynthesis from this genus was identifi ed,and tirucallane-type were reported to be 37.6% of the totalcompounds. The anti-malarial, anti-feedant, antimicrobial,anti-infl ammatory, antioxidant, vasodilative eff ect, anti-viral,cortisone reductase, and cytotoxic activities of the extractwere also evaluated. The results showed the necessity ofusing the triterpenoid compounds from the Dysoxylum genusin traditional medicine and the discovery of new drugs.