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RISS 인기검색어
- 검색키워드
- 저자 : Toshishige Shibamoto (검색결과 2 건)
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Wei Yang,Toshishige Shibamoto,Yuhichi Kuda,Tao Zhang,Mamoru Tanida,Yasutaka Kurata 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.1
Purpose: Patients treated with propranolol, a nonselective β-adrenoceptor antagonist, develop severe anaphylaxis, but the mechanism remains unknown. We determined effects of β1- and β2-adrenoceptor antagonists on the anaphylaxis-induced increase in vascular permeability in mice. Methods: In anesthetized ovalbumin-sensitized C57BL mice, mean arterial blood pressure (MBP) was measured, and Evans blue dye extravasation and hematocrit (Hct) were assessed at 20 minutes after antigen injection. The following pretreatment groups (n=7/group) were studied: (1) sensitized control (non-pretreatment), (2) propranolol, (3) the selective β2-adrenoceptor antagonist ICI 118,551, (4) the selective β1-adrenoceptor antagonist atenolol, (5) adrenalectomy, (6) the selective β2-adrenoceptor agonist terbutaline, and (7) non-sensitized groups. Results: The antigen injection decreased MBP, and increased Hct and vascular permeability in the kidney, lung, mesentery, and intestine, but not in the liver or spleen. Pretreatment with ICI 118,551, propranolol and adrenalectomy, but not atenolol, reduced the survival rate and augmented the increases in Hct and vascular permeability in the kidney, intestine, and lung as compared with the sensitized control group. Pretreatment with terbutaline abolished the antigen-induced alterations. Plasma epinephrine levels were increased significantly in the sensitize control mice. Conclusions: Blockade of β2-adrenoceptor can deteriorate systemic anaphylaxis by augmenting hyperpermeability-induced increase in plasma extravasation by inhibiting beneficial effects of epinephrine released from the adrenal glands in anesthetized mice.
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MRI Reveals Edema in Larynx (But Not in Brain) During Anaphylactic Hypotension in Anesthetized Rats
Ichiro Toyota,Mamoru Tanida,Toshishige Shibamoto,Mofei Wang,Yasutaka Kurata,Hisao Tonami 대한천식알레르기학회 2013 Allergy, Asthma & Immunology Research Vol.5 No.6
Purpose: Anaphylactic shock is sometimes accompanied by local interstitial edema due to increased vascular permeability. We performed magneticresonance imaging (MRI) to compare edema in the larynx and brain of anesthetized rats during anaphylactic hypotension versus vasodilator-inducedhypotension. Methods: Male Sprague Dawley rats were subjected to hypotension induced by the ovalbumin antigen (n=7) or a vasodilator sodiumnitroprusside (SNP; n=7). Apparent diffusion coefficient (ADC) and T2-relaxation time (T2RT) were quantified on MRI performed repeatedly for upto 68 min after the injection of either agent. The presence of laryngeal edema was also examined by histological examination. Separately, the occurrenceof brain edema was assessed by measuring brain water content using the wet/dry method in rats with anaphylaxis (n=5) or SNP (n=5) andthe non-hypotensive control rats (n=5). Mast cells in hypothalamus were morphologically examined. Results: Mean arterial blood pressure similarlydecreased to 35 mmHg after an injection of the antigen or SNP. Hyperintensity on T2-weighted images (as reflected by elevated T2RT) was foundin the larynx as early as 13 min after an injection of the antigen, but not SNP. A postmortem histological examination revealed epiglottic edema inthe rats with anaphylaxis, but not SNP. In contrast, no significant changes in T2RT or ADC were detectable in the brains of any rats studied. In separateexperiments, the quantified brain water content did not increase in either anaphylaxis or SNP rats, as compared with the non-hypotensive controlrats. The numbers of mast cells with metachromatic granules in the hypothalamus were not different between rats with anaphylaxis and SNP,suggesting the absence of anaphylactic reaction in hypothalamus. Conclusion: Edema was detected using the MRI technique in the larynx duringrat anaphylaxis, but not in the brain.
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