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RISS 인기검색어
- 검색키워드
- 저자 : Toshiharu Nakajima (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Nagahisa, Keisuke,Nakajima, Toshiharu,Yoshikawa, Katsunori,Hirasawa, Takashi,Katakura, Yoshio,Furusawa, Chikara,Shioya, Suteaki,Shimizu, Hiroshi The Korean Society for Biotechnology and Bioengine 2005 Biotechnology and Bioprocess Engineering Vol.10 No.5
The effect of carbon dioxide on yeast growth was investigated during the cultivation of pH 5.0 and pH 6.8. by replacing the nitrogen part with carbon dioxide under aerobic conditions. The values of the specific growth rate under pH 5.0 and pH 6.8 conditions became 64.0% and 46.9%, respectively, compared to those before the change in gas composition. This suggests that the effect of carton dioxide was greater pronounced in pH 6.8 than in pH 5.0. The genome-wide transcriptional response to elevated carbon dioxide was examined using a DNA microarray. As for upregulated genes, it was noteworthy that 3 genes were induced upon entry into a stationary phase and 6 genes were involved in stress response. Of 53 downregulated genes, 22 genes were involved in the ribosomal biogenesis and assembly and 5 genes were involved in the lipid metabolism. These facts suggest that carbon dioxide could bring the cell conditions partially to a stationary phase. The ALD6 gene encoding for cytosolic acetaldehyde dehydrogenase was downregulated, which would lead to a lack of cell components for the growth. The downregulation of ALD6 was greater in pH 6.8 than in pH 5.0. consistent with physiological response. This suggests that it might be the most effective factor for growth inhibition.
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Hiroshi Shimizu,Keisuke Nagahisa,Toshiharu Nakajima,Katsunori Yoshikawa,Takashi Hirasawa,Yoshio Katakura,Chikara Furusawa,Suteaki Shioya 한국생물공학회 2005 Biotechnology and Bioprocess Engineering Vol.10 No.5
The effect of carbon dioxide on yeast growth was investigated during the cultivation of pH 5.0 and pH 6.8, by replacing the nitrogen part with carbon dioxide under aerobic conditions. The values of the specific growth rate under pH 5.0 and pH 6.8 conditions became 64.0% and 46.9%, respectively, compared to those before the change in gas composition. This suggests that the effect of carbon dioxide was greater pronounced in pH 6.8 than in pH 5.0. The genome-wide transcriptional response to elevated carbon dioxide was examined using a DNA microarray. As for upregulated genes, it was noteworthy that 3 genes were induced upon entry into a stationary phase and 6 genes were involved in stress response. Of 53 downregulated genes, 22 genes were involved in the ribosomal biogenesis and assembly and 5 genes were involved in the lipid metabolism. These facts suggest that carbon dioxide could bring the cell conditions partially to a stationary phase. The ALD6 gene encoding for cytosolic acetaldehyde dehydrogenase was downregulated, which would lead to a lack of cell components for the growth. The downregulation of ALD6 was greater in pH 6.8 than in pH 5.0, consistent with physiological response. This suggests that it might be the most effective factor for growth inhibition.
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Effect of Venous Superdrainage on a Four-Territory Skin Flap Survival in Rats
Chang, Hak,Minn, Kyung Won,Imanishi, Nobuaki,Minabe, Toshiharu,Nakajima, Hideo Williams & Wilkins 2007 Plastic and reconstructive surgery Vol.119 No.7
BACKGROUND:: In a previous report, the authors demonstrated that distal arterial supercharging is more effective at increasing flap survival. There is no doubt of the benefit of arterial augmentation in flap surgery, but the effect of venous superdrainage is still controversial. The purpose of this study was to investigate how venous augmentation could generate larger flap survival areas with different superdrainage positions in rats. METHODS:: A four-territory skin flap, developed by the authors, was used. Forty rats were divided into four groups, as follows: group 1, flaps based only on the deep circumflex iliac artery and vein; group 2, flaps superdrained with the ipsilateral superficial inferior epigastric vein; group 3, flaps superdrained with the contralateral superficial inferior epigastric vein; and group 4, flaps superdrained with the contralateral deep circumflex iliac vein. On the fourth postoperative day, the flaps were assessed by measurements of necrosis and survival areas. Vascular changes produced by venous augmentation were evaluated angiographically. RESULTS:: Compared with group 1 (mean flap survival, 37.8 ± 5.0 percent), the flap survival areas were significantly greater in the superdrainage flap groups (group 2, 57.4 ± 6.5 percent, p < 0.001; group 3, 72.4 ± 21.3 percent, p < 0.001, and group 4, 89.2 ± 18.8 percent; p < 0.001). Angiographic assessment of the flaps revealed dilatation of the choke vein between the territories and reorientation of dilated veins along the long axes of the flaps. CONCLUSIONS:: This study demonstrates that venous augmentation is also effective for increasing flap survival, and the distal procedure is more effective than the proximal procedure in arterial supercharging.
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