http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Tolulope Mary Olaleye (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Kayode Komolafe,Tolulope Mary Olaleye,Olaposi Idowu Omotuyi,Aline Augusti Boligon,Margareth Linde Athayde,Akintunde Afolabi Akindahunsi,Joao Batista Teixeira da Rocha 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.4
Aqueous-methanolic extract of Parkia biglobosa bark (PBB) was screened for its polyphe- nolic constituents, in vitro antioxidant activity, and effect on mitochondria redox status. The in vitro antioxidant activity was assessed by using the scavenging abilities and the reducing powers of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2 0 -azino-bis(3- ethylbenzothiazoline-6-sulfonic acid) (ABTS) diammonium salt radical cation against Fe 3þ . Subsequently, the ability of PBB to inhibit lipid peroxidation induced by FeSO 4 (10 mm) and its metal-chelating potential were investigated. The effects of the extract on basal reactive oxygen species (ROS) generation and on the mitochondrial membrane potential (DJm) in isolated mitochondria were determined by using 2 0 , 7 0 -dichlorodihy- drofluorescin (DCFH) oxidation and safranin fluorescence, respectively. PBB mitigated the Fe(II)-induced lipid peroxidation in rat tissues and showed dose-dependent scav- enging of DPPH (IC 50 : 98.33 ± 10.0 mg/mL) and ABTS. (trolox equivalent antioxidant concentration, TEAC value = 0.05), with considerable ferric-reducing and moderate metal-chelating abilities. PBB caused slight decreases in both the liver and the brain mitochondria potentials and resulted in a significant decrease (p < 0.001) in DCFH oxida- tion. Screening for polyphenolics using high-performance liquid chromatography coupled to a diode array detector (HPLC-DAD) revealed the presence of caffeic acid, gallic acid, catechin, epigalocatechin, rutin, and quercetin. These results demonstrate for the first time the considerable in vitro antioxidant activity and favorable effect of PBB on mito- chondria redox status and provide justification for the use of the plant in ethnomedicine.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
