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- 저자 : Tijjani Salihu Shinkafi (검색결과 1 건)
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Shakir Ali,Amena Mahmood,Indusmita Routray,Tijjani Salihu Shinkafi,Kazim Sahin,Omer Kucuk 대한암예방학회 2014 Journal of cancer prevention Vol.19 No.4
Background:Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound thatcan protect liver against injury. Clove, besides eugenol, also contains other pharmacologically active phytochemicals such as β-sitosteroland ascorbic acid. This study reports the effect of eugenol-rich fraction (ERF) of clove on liver cirrhosis induced by thioacetamide. Methods:Cirrhosis of the liver, which predisposes to hepatocellular carcinoma, was induced by administering thioacetamide (0.03%)in drinking water for 16 weeks. Cirrhotic animals were divided into two groups; the treated group was administered ERF for 9 weeks,one week after discontinuation of thioacetamide, while the other group received normal saline for a similar duration of time. Results:The treatment with ERF, as determined by histopathology and through a battery of biochemical markers of hepatic injury, oxidativestress and drug metabolizing enzymes, significantly ameliorated the signs of liver cirrhosis. It lowered the elevated levels ofalkalinephosphatase, γ-glutamyl transferase and other biochemical changes in liver cirrhosis. Histopathology of the liver corroborated the effectof ERF with biochemical findings. ERF treatment further inhibited cell proliferation, as demonstrated by reduced [3H]-thymidine uptake. Conclusions:Data provide evidence supporting the protective action of ERF on liver cirrhosis. The study assumes significance becausecirrhosis predisposes the liver to cancer, which is characterized by abnormal cell proliferation. ERF in this study is reportedto inhibithepatic cell proliferation and at the same time decrease oxidative stress, which might be the mechanism of protection against liver cirrhosis.
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