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Jane Teas,Lewis E. Braverman,Mindy S. Kurzer,Sam Pino,Thomas G. Hurley,James R. Hebert 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
Seaweeds and soy are two commonly eaten foods in Asia. Both have been reported to affect thyroid function,seaweed because of its iodine content and soy because of its goitrogenic effect. Twenty-five healthy postmenopausal women(mean age 58 years) completed a double-blinded randomized crossover study. Ten capsules (5 g/day) of placebo or seaweed(Alaria esculenta), providing 475 .g of iodine/day, were consumed daily for 7 weeks. A powdered soy protein isolate (So-lae Co., St. Louis, MO), providing 2 mg of isoflavones/kg of body weight, was given daily during the last week of each treat-ment arm. On average, this provided 141.3 mg of isoflavones/day and 67.5 g of protein/day. Blood samples and 48-hour urinesamples were collected before and after each intervention period, and urinary I/C (.g of iodine/g of creatinine) and serumthyroxine, free thyroxine index, total triiodothyronine, and thyroid stimulating hormone (TSH) were measured. Seaweed in-gestion increased I/C concentrations (P. .0001) and serum TSH (P. .0001) (1.69. 0.22 vs. 2.19. 0.22 .U/mL, mean.SE). Soy supplementation did not affect thyroid end points. Seven weeks of 5 g/day seaweed supplementation was associatedwith a small but statistically significant increase in TSH. Soy protein isolate supplementation was not associated with changesin serum thyroid hormone concentrations.
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