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Su-Young Lee,Ji-Yoon Hong,Tae Yang Kim,Jin-A Yu,Gi Jung Kim,Ye Lim Jang,Tessema Haimanot Miticu,Jung Bae Oh,Young-In Kwon 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, the effect of long-term intake of Jeju barley extract (JBE) on the anti-obesity was evaluated using diet-induced obesity C57BL/6 mouse model. The animal experiment was conducted for 8 weeks, and a total of 20 mice were divided into 4 groups: a normal diet group (ND), high-fat diet group (HFD), barley 0.3 g/kg group (BL) and barley 0.5 g/kg group (BH). The JBE administration group was fed a high-fat diet and the sample was orally administered twice a day. As a result of measuring the change in body weight every other day, it was confirmed that the BL and BH group showed less weight gain than the HFD group. After sacrifice, various adipose tissue weights, lipid levels {total cholesterol (TC), triglycerides (TG), HDL-Cholesterol (HDL-C), LDL-Cholesterol (LDL-C)}, adiponectin, leptin, TNF-α, IL-6 and insulin were measured. TC, TG and LDL-C levels were significantly lower in the BL group than in the HFD group. It was also confirmed that the leptin level was significantly lower than that of the HFD group. These results indicate that proper intake of JBE may reduce weight gain and improve obesity-related indicators such as adiponectin, leptin, TC, TG and HDL-C levels.
In-vitro and In-vivo Anti-hyperglycemic Effects of Nipa palm (Nypa fruticans Wurmb) Extract
Kyung-Tae Kwon,Gi Jung Kim,Tae Yang Kim,Jin-A Yu,Su-Young Lee,Ji-Yoon Hong,Ye Lim Jang,Tessema Haimanot Miticu,Young-In Kwon 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, Nipa palm extract by solvent were investigated for their anti-hyperglycemic and using in-vitro, in-vivo animal models. In-vitro study, we investigated the inhibitory activities of Nipa palm stems and flower extracts by solvent against various digestive enzymes such as α-glucosidase, sucrase, maltase, and glucoamylase. In addition, α-amylase inhibitory activity, oxygen radical absorbance capacity, total phenolic and flavonoid content were measured. Among solvent extract, stem water extract (SWE) had the highest α-glucosidase inhibitory activity (3.6 mg/ml of IC50) and high sucrase inhibitory activity (0.28 mg/ml IC50). Furthermore, the extracts were investigated for in-vivo post-prandial blood anti-hyperglycemic effect using Sprague-Dawley(SD) rat model. The maximum blood glucose concentration(Cmax) in SWE-treated SD-rat (0.5 g-ΚBE/kg-bw) was significantly lower than in untreated SD-rats (199.9±10.4 vs. 222.0±15.4 hr·mg/dL, p<0.05). These results indicate that SWE may improve exaggerated post-prandial spikes in blood glucose via inhibition of intestinal α-glucosidase and thus delays carbohydrate absorption in colon.