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- 저자 : Tejedor-Tejedor, M. Isabel (검색결과 3 건)
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Tejedor Ana,Deiros Carme,Bijelic Lana,García Marta 대한마취통증의학회 2023 Anesthesia and pain medicine Vol.18 No.2
Background: Regional anesthesia techniques are commonly used for postoperative pain management during laparoscopic surgery. Our aim was to compare the analgesic efficacy of pre-incisional subcutaneous wound infiltration (WI) with that of the transversus abdominis plane (TAP) block as part of a multimodal analgesic approach in laparoscopic radical prostatectomy.Methods: In this prospective, double-blinded, randomized controlled clinical trial, 60 patients were assigned to either TAP or WI group. The main outcome was acute postoperative pain control assessed using the mean numeric rating scale (NRS) at the 24 hours postoperatively. The secondary outcomes were opioid requirements, procedure-related complications, overall complications, and length of stay.Results: In this study, 60 patients were randomized: 30 to TAP group and 28 to WI (two were excluded due to conversion to open surgery). We found no significant difference in the median (1Q, 3Q) NRS scores during the 24 h postoperatively neither at rest (TAP, 0 (0, 1) vs. WI, 0 (0, 1), P = 0.812), nor during movement (TAP, 1 (0, 2) vs. WI, 1 (0, 2), P = 0.708). There were no statistical differences in the postoperative intravenous morphine requirements in the TAP vs. WI groups during the same period (1.7 ± 3.1 vs. 1.8 ± 4.1 mg; P = 0.910). Only one patient in the TAP group presented with postoperative nausea and vomiting.Conclusions: Both pre-incisional subcutaneous WI and TAP blockade were associated with very low pain scores as part of a non-opioid multimodal analgesic regimen in laparoscopic radical prostatectomy. This study did not demonstrate the benefits of WI over TAP.
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Essential Role for dlg in Synaptic Clustering of Shaker K^+ Channels In Vivo
Tejedor, Francisco J.,Bokhari, Amr,Rogero, Oscar,Gorczyca, Michael,Zhang, Jiangwen,Kim, Eunjoon,Sheng, Morgan,Budnik, Vivian 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-
The assemblage of specific ion channels and repectors at synaptic sites is crucial for signaling betweem pre-and postsynaptic cells. However, the mechanism by which proteins are targeted to and cluatered at synapses are poorly understood. Here we show that the producct of the Drosophila discs-large gene, DLG, is colocalized with Shaker K^+ chammels, which are clustered at glutamatergic synapses at the larval neuromuscular juction. In heterologous cells. DLG can cluster Shaker-type K^+ channels,and in the yeast two-hybrid system,the DLG PDZ1-2 domains bind directly to the DLG-Shaker interactions are required in vivo for Shaker clustering at the neuromuscular junction. Synaptic cluatering of Shaker channels is abolished not only by mutations in dlg but also by a mutation in Shaker that deletes its C-terminal DLG binding motif. Analyses of various dlg mutant alleles suggest that channel clustering and synaptic targeting functions depend on distinct DLG domains. These studies demonstrate for the first time that DLG plats an important role in sunaptic organization in vivo that correlates with its ability to bind directly to specific menbrane proteins of the synapse.
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Plasmon-Enhanced Photoelectrochemical Water Splitting with Size-Controllable Gold Nanodot Arrays
Kim, Hyung Ju,Lee, Sang Ho,Upadhye, Aniruddha A.,Ro, Insoo,Tejedor-Tejedor, M. Isabel,Anderson, Marc A.,Kim, Won Bae,Huber, George W. American Chemical Society 2014 ACS NANO Vol.8 No.10
<P>Size-controllable Au nanodot arrays (50, 63, and 83 nm dot size) with a narrow size distribution (±5%) were prepared by a direct contact printing method on an indium tin oxide (ITO) substrate. Titania was added to the Au nanodots using TiO<SUB>2</SUB> sols of 2–3 nm in size. This created a precisely controlled Au nanodot with 110 nm of TiO<SUB>2</SUB> overcoats. Using these precisely controlled nanodot arrays, the effects of Au nanodot size and TiO<SUB>2</SUB> overcoats were investigated for photoelectrochemical water splitting using a three-electrode system with a fiber-optic visible light source. From UV–vis measurement, the localized surface plasmon resonance (LSPR) peak energy (<I>E</I><SUB>LSPR</SUB>) increased and the LSPR line width (Γ) decreased with decreasing Au nanodot size. The generated plasmonic enhancement for the photoelectrochemical water splitting reaction increased with decreasing Au particle size. The measured plasmonic enhancement for light on/off experiments was 25 times for the 50 nm Au size and 10 times for the 83 nm Au nanodot size. The activity of each catalyst increased by a factor of 6 when TiO<SUB>2</SUB> was added to the Au nanodots for all the samples. The activity of the catalyst was proportional to the quality factor (defined as <I>Q</I> = <I>E</I><SUB>LSPR</SUB>/Γ) of the plasmonic metal nanostructure. The enhanced water splitting performance with the decreased Au nanodot size is probably due to more generated charge carriers (electron/hole pair) by local field enhancement as the quality factor increases.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-10/nn504484u/production/images/medium/nn-2014-04484u_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn504484u'>ACS Electronic Supporting Info</A></P>
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