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Spontaneous pulmonary alveolar proteinosis in a C57BL/6 mouse: Case report
Warisraporn Tangchang(Warisraporn Tangchang ),Eun-Sang Cho(Eun-Sang Cho),Won Kee Yoon(Won Kee Yoon),Hyo-Jung Kwon(Hyo-Jung Kwon),Hwa-Young Son(Hwa-Young Son) 한국예방수의학회 2023 예방수의학회지 Vol.47 No.2
This case report describes the pathological features of pulmonary alveolar proteinosis(PAP) in mouse. Grossly, multiple irregular yellow-grey patches were observed on the lung surface of a C57BL/6 mouse. Histopathologically, the alveolar walls were thickened by type II cell hyperplasia and cellular infiltrates, and the bronchioles and alveolar lumens were filled with amorphous eosinophilic lipoproteinaceous material. This material was positive for Periodic acid-Schiff stain. Gomori methenamine silver staining was negative. Immunohistochemical staining showed that cells in the alveolar wall and lumen were positive for surfactant protein B, chitinase-like protein-3, and CD68. As a result, PAP was diagnosed. This is a rare case of spontaneous PAP in mice, and we report the histopathological characteristics along with the literature.
Warisraporn Tangchang,YunHyeok Kim,Ye-In Oh,Byung-Woo Lee,Hyunwook Kim,Byungil Yoon 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.6
It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) markers. To generate a tumor xenograft model, we subsequently transplanted the tissue pieces from the PAC into athymic nude mice. Immunohistochemical examination was performed for diagnostic (TTF-1, Napsin A, and SP-A) and CSC markers (CD44 and CD133). The use of CSC markers together with diagnostic markers can improve the detection and diagnosis of canine primary and metastatic adenocarcinomas.
Hydrocotyle ramiflora attenuates benign prostatic hyperplasia in the rats
Suyoung Park,Eun Bok Baek,Eun-Ju Hong,Eunhye Jung,Warisraporn Tangchang,Hwa-Young Son,Hyo-Jung Kwon 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Benign prostatic hyperplasia (BPH) is a common urogenital disorder that affects up to 85% of males who are over 50 years-old. BPH is characterized by the increased proliferation of epithelial and stromal cells of the prostate. Hydrocotyle ramiflora (HR) of the family Apiaceae, is a perennial plant. HR is known as the induction of diuresis and antipyretic activity. And HR is used for therapy of disease of urinary system, such as ischuria and cystitis. The present study evaluated the therapeutic effects of HR on a testosterone-induced BPH rats. We induced BPH to rats by subcutaneous injections (s.c) of testosterone propionate (TP) daily for four weeks. Rats were also administered daily oral gavage of HR (150 mg/kg) or vehicle. After four weeks of induction, all animals were euthanized humanely and their prostate glands were removed, weighed and processed for further analysis, including histopathological examination, immunohistochemistry, real-time PCR, and western blot analysis. Administration of HR to TP-induced BPH rats considerably reduced prostate weight, epithelial thickness and expression of proliferating cell nuclear antigen (PCNA). The expression of cleavage of caspase-3 was markedly increased by HR-treatment in the rats. In addition, HR decreased the level of pro-inflammatory cytokines, including interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) and suppressed the expression of Vascular Endothelial Growth Factor(VEGF) and Transforming Growth Factor beta 1 (TGF-β1). The activation of nuclear factor-κB (NF-κB) and The expression of cyclooxygenase-2 (COX-2) were reduced by HR treatment in a TP-induced BPH rat model. These results indicate that HR is beneficial in the treatment of BPH by promoting the apoptosis and inhibiting the inflammation. Therefore, HR could be a useful agent in the treatment of BPH.
Eun Bok Baek,Suyoung Park,Eun-Ju Hong,Warisraporn Tangchang,Hwa-Young Son,Hyo-Jung Kwon 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate gland, resulted from hyperplastic changes of prostate epithelial and stromal cells and it can be lead to lower urinary tract symptoms. Panicum dichotomiflorum (PD) is an annual grass distributing throughout the world. This study was aimed to evaluate the protective effect of PD extract on benign prostatic hyperplasia (BPH) in a rat model of testosterone-induced BPH. BPH of rat was induced by daily subcutaneous (s.c) administration of testosterone propionate (TP) 3 mg/kg for four weeks. Simultaneously, rats were also administered daily oral gavage of PD (150 mg/kg), finasteride (10 mg/kg) as a positive control or vehicle. After final treatment, all animals were sacrificed humanely and prostates of each animal were isolated, weighed and collected for further analysis. Administration of PD to testosterone-induced BPH rats notably reduced relative prostate weight and concentrations of prostatic dihydrotestosterone (DHT) and serum testosterone. Epithelial thickness and expression of proliferating cell nuclear antigen (PCNA) and cyclin D1 were markedly suppressed by PD treatment. In addition, protein expressions of the B-cell lymphoma 2 (Bcl-2) and cleaved caspase-3 were reduced PD-treated rats. PD decreased the levels of growth factors including transforming growth factor-beta1 (TGF-β1) and vascular endothelial growth factor (VEGF) and protein expression of phospho-Akt. Further investigation showed that PD suppressed testosterone-induced prostatic inflammation and inflammatory cytokines including tumor necrosis factor- α (TNF-α), interleukin (IL)-6 and IL-8. Taken together, PD protects from BPH progression by enhancing apoptosis and inhibiting growth factor signaling and inflammatory cytokines, suggesting that PD has potential to protect from BPH progression accompanied by inflammation.