http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Takikita, M. (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Chung, J.Y.,Kitano, H.,Takikita, M.,Cho, H.,Noh, K.H.,Kim, T.W.,Ylaya, K.,Hanaoka, J.,Fukuoka, J.,Hewitt, S.M. W. B. Saunders Co ; Centrum Philadelphia 2013 Human pathology Vol.44 No.4
Synaptonemal complex protein 3 is a marker for cell transformation that has prognostic significance in various cancers. However, the prognostic significance of synaptonemal complex protein 3 has not been studied in non-small cell lung cancer. To investigate the potential correlation between synaptonemal complex protein 3 and various clinicopathologic parameters, we assessed the expression of synaptonemal complex protein 3 in archival tumor tissues from 258 patients with non-small cell lung cancer by immunohistochemical staining. By immunofluorescence, synaptonemal complex protein 3 was detected in both the cytoplasmic and nuclear fractions of NCI-H1299 cell. In tumor samples, synaptonemal complex protein 3 is detected as cytoplasmic expression pattern and observed in 50 clinical samples (19.4%) by immunohistochemical staining. Synaptonemal complex protein 3 expression was correlated with T status (P = .008), lymph node metastasis (P = .010), tumor types (P = .019), and pleural invasion (P = .005). In multivariate analysis of patients with early stage disease, increased synaptonemal complex protein 3 expression predicted worse overall survival in early stage (stage I and II) with pT1 status (P = .041). These results suggest that positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival and may provide clues in the identification of patients for adjuvant therapy.
-
( Han Byoul Cho ),( Joon Yong Chung ),( Mikiko Takikita ),( Stephen M Hewitt ),( Jae Hoon Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
The protein kinase B (AKT) pathway plays a key role in the regulation of cell death and survival, and has been proposed as a central signaling event in carcinogenesis. We investigated the expression of MKRN1, which is a transcriptional co-regulator and an E3 ligase, and sought to define the role of AKT pathway in cervical neoplasias. One hundred eighty three cervical cancer, 415 cervical intraepithelial neoplasia, and 400 matched nonadjacent normal tissues were arrayed into tissue microarrays. MKRN1, phosphorylated AKT (pAKT), phosphorylated mammalian target of rapamycin (pmTOR), and total phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein expressions were assessed by immunohistochemistry (IHC) and the relationship between MKRN1 expression and clinicopathologic parameters including survival data was studied. MKRN1, pAKT, and pmTOR expressions were significantly increased in cervical cancer cases compared with normal epitheliums (p<0.001 for all markers), and this increased expression of MKRN1 was significantly associated with tumor stage (p=0.018) and tumor grade (p<0.001). Expression of MKRN1 was positively associated with pAKT expression (p=0.023), while negatively associated with PTEN expression (p=0.016) in cervical cancer specimens. In multivariate analysis, MKRN1+/pAKT+ (HR = 4.76 [1.66-13.58], p=0.004), pAKT+ (HR = 2.97 [1.02-8.06], p=0.045), and lymph node metastasis (HR = 3.94 [1.07-14.45], p=0.039) were independent prognostic factors for overall survival. This study provides evidence of an association between AKT pathway and cervical carcinogenesis and shows that MKRN1/pAKT expression predicts poor prognosis in cervical cancer. Our findings also suggest that future research assessing its clinical usefulness would be worthwhile.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
