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Takao Fujii,Osamu Kaneko 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
A new configuration of ILQ servo system based on dynamic output feedback is presented together with its output feedback gain matrices by proper choice of a certain design parameter of the ILQ design method. Noticing its same feedback structure as that of I-PD servo system for the particular case of SISO systems with relative order two, this renewed ILQ design method is then applied to FRIT based I-PD controller tuning for a linear second order SISO system with time delay. A numerical design example is also shown to verify the usefulness of this tuning method.
Hormetic effects of regular exercise in aging: correlation with oxidative stress
Goto, Sataro,Naito, Hisashi,Kaneko, Takao,Chung, Hae Young,Radá,k, Zsolt NATIONAL RESEARCH COUNCIL OF CANADA 2007 APPLIED PHYSIOLOGY NUTRITION AND METABOLISM Vol.32 No.5
<P> To explore mechanisms of the beneficial consequences of regular exercise, we studied the effects of regular swimming and treadmill exercise on oxidative stress in the brain and liver of rats. Protein carbonyl was significantly reduced and the activity of proteasome was upregulated in the brain extracts of young and middle-aged animals after 9 weeks of swimming training. Furthermore, their cognitive functions were significantly improved. In separate experiments, the activation of transcription nuclear factor κB was attenuated in the liver of old rats after 8 weeks of regular treadmill exercise and the DNA binding activity of glucocorticoid receptor reduced with age was restored, suggesting that inflammatory reactions are alleviated by the regimen. This was accompanied by upregulation of the glutathione level and reduced reactive oxygen species generation. Similar training reduced the 8-oxodeoxyguanosine content in the nuclear and mitochondrial DNA of the liver of old rats. Thus, these findings, together with reports of other investigators, suggest that moderate regular exercise attenuates oxidative stress. The mild oxidative stress possibly elicited by regular exercise appears to manifest a hormesis-like effect in nonmuscular tissues, constituting beneficial mechanisms of exercise by adaptively upregulating various antioxidant mechanisms, including antioxidative and repair-degradation enzymes for damaged molecules. Importantly, the adaptation induced by regular exercise was effective even if initiated late in life. </P>
Masaki Nishiguchi,Hiroki Kikuyama,Tetsufumi Kanazawa,Atsushi Tsutsumi,Takao Kaneko,Hiroyuki Uenishi,Yasuo Kawabata,Seiya Kawashige,Jun Koh,Hiroshi Yoneda 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.4
ObjectiveaaElectroconvulsive therapy (ECT) is a reasonable option for intractable depression or schizophrenia, but a mechanism of action has not been established. One credible hypothesis is related to neural plasticity. Three genes (Oct4, Sox2, c-Myc) involved in the induction of induced pluripotent stem (iPS) cells are Wnt-target genes, which constitute a key gene group involved in neural plasticity through the TCF family. Klf4 is the other gene among Yamanaka’s four transcription factors, and increases in its expression are induced by stimulation of the canonical Wnt pathway. MethodsaaWe compared the peripheral blood gene expression of the four iPS genes (Oct4, Sox2, c-Myc, and Klf4) before and after modified ECT (specifically ECT with general anesthesia) of patients with intractable depression (n=6) or schizophrenia (n=6). Using Thymatron ten times the total bilateral electrical stimulation was evoked. ResultsaaBoth assessments of the symptoms demonstrated significant improvement after mECT stimulation. Expression of all four genes was confirmed to increase after initial stimulation. The gene expression levels after treatment were significantly different from the initial gene expression in all twelve cases at the following treatment stages: at the 3rd mECT for Oct4; at the 6th and 10th mECT for Sox2; and at the 3rd, 6th and 10th mECT for c-Myc. ConclusionaaThese significant differences were not present after correction for multiple testing; however, our data have the potential to explain the molecular mechanisms of mECT from a unique perspective. Further studie should be conducted to clarify the pathophysiological involvement of iPS-inducing genes in ECT.