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- 저자 : Taekjoon Yoon (검색결과 2 건)
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Heejung Park,Taekjoon Yoon 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The effects of red ginseng extracts (RG) and γ-aminobutyric acid (GABA) on immunostimulatory activity and tumor metastasis inhibition in mice were investigated. The proliferative activity of splenocytes was significantly higher in the RG + GABA (RG-GA) group than in RG or GABA alone. The RG-GA-administered group showed increased production of interleukin (IL)-6 and GM-CSF compared to that in the RG or GABA groups. BM cell proliferation was significantly induced when the supernatant of Peyer’s patch cells obtained from GA-RG group was added. In the experimental tumor metastasis model, RG-GA treatment produced a significant anti-tumor metastatic effect. In addition, oral administration of RG-GA not only increased the cytotoxic activity of NK cells against YAC-1 cells, but also significantly increased IFN-γ and granzyme B concentrations in the culture supernatant. The blood level of interferon-γ, IL-17, and IL-21 were significantly higher in RG-GA group compared to monotreated group. Therefore, RG has a synergistic effect with GABA that enhances the host defense system against foreign materials. This research was funded by Ministry of SMEs and Startups.
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Heejung Park,Taekjoon Yoon 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The purpose of this study was to evaluate the gastro-protective effect of cabbage extract (sulforaphane content was 5.19 mg/L and S-methylmethionine was 469.28 μg/L). In vitro study, the lipopolysaccharide (LPS)-treated group had an increased nitic oxide (NO) and interleukin (IL)-6 activity compared to normal group, and NO and IL-6 level was decreased when the cabbage extract was treated in the manner of dose. In the gastritis-induced mice group, severe hemorrhagic mucosal damage was observed in the entire area of the stomach due to bleeding marks. The degree of gastric mucosal damage was decreased in dose dependent manner. Mucosal erosion in the gastritis model was also ameliorated in the cabbage extract administration group. The blood level of histamine was significantly increased in the gastritis-induced animal model, and the secretion of histamine was reduced in the 23 mg/L treated group of cabbage extract. In conclusion, cabbage extract can help inhibit gastrointestinal disorders by improving the protective barrier. This research was funded by Leading Technology Development Project based on 4th Industrial Revolution from Chungcheongbuk-do.
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