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Potentially Cytotoxic Triterpenoids from the Root Bark of Siphonodon celastrineus Griff.
Niampoka, Chokchai,Suttisri, Rutt,Bavovada, Rapepol,Takayama, Hiromitsu,Aimi, Norio The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.5
A new oleanane-triterpene, 3${\beta}$-acetoxy-11${\alpha}$-benzoyloxy-13${\beta}$-hydroxyolean-1 2-one (1), was isolated along with a known quinone-methide triterpene, pristimerin (2), from the root bark of Siphonodon celastrinneus Griff., a Thai medicinal plant of the family Celastraceae. Their structures were determined based on spectroscopic analysis.
A New Acyclic Diterpene Acid and Bioactive Compounds from Knema glauca
Noppadon Rangkaew,Rutt Suttisri,Masataka Moriyasu,Kazuko Kawanishi 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.5
Investigation of the chemical constituents of the fruits of Knema glauca (Myristicaceae) yielded a new acyclic diterpene acid, named glaucaic acid 4, together with four acylphenols, including 1-(2,6-dihydroxyphenyl) tetradecan-1-one 1, malabaricone A 6, dodecanoylphloroglucinol 7 and 1-(2,4,6-trihydroxyphenyl)-9-phenylnonan-1-one 8, two lignans sesamin 2 and asarinin 3, and a flavan, myristinin D 5. In addition, myristinin A 9 and (±)-7,4'-dihydroxy-3'- methoxyflavan 10 were isolated from its leaves and stems, respectively. When tested against small-cell lung cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines, compounds 1, 6-8 and 10 displayed weak to moderate cytotoxicity. The acylphenols 6-8 displayed antituberculosis activity against the microbe Mycobacterium tuberculosis with MIC values of 25, 50 and 100 μg/mL, respectively, and antiviral activity against herpes simplex virus type 1, with 7 as the most active compound (IC50 = 3.05 μg/mL). Malabaricone A 6 was also active against the malarial parasite Plasmodium falciparum with an IC50 value of 2.78 μg/mL.
Potentially Cytotoxic Triterpenoids from the Root Bark of Siphonodon celastrineus Griff.
Chokchai Niampoka,Rutt Suttisri,Rapepol Bavovada,Hiromitsu Takayama,Norio Aimi 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.5
A new oleanane-triterpene, 3β-acetoxy-11α-benzoyloxy-13β-hydroxyolean-12-one (1), was isolated along with a known quinone-methide triterpene, pristimerin (2), from the root bark of Siphonodon celastrineus Griff., a Thai medicinal plant of the family Celastraceae. Their structures were determined based on spectroscopic analysis.
A New Sesquiterpene and Other Terpenoid Constituents of Chisocheton penduliflorus
Phongmaykin, Jarinporn,Kumamoto, Takuya,Ishikawa, Tsutomu,Suttisri, Rutt,Saifah, Ekarin 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
A new aromadendrane sesquiterpene, allo-aromadendrane-10${\alpha}$, 14-diol (3), was isolated from Chisocheton penduliflorus (Meliaceae), along with two known sesquiterpenes: allo-aromadendrane-10${\beta}$, 13, 14-triol (7). Six dammarane triterpenoids, including cabraleadiol (1), eichlerialactone (4), cabraleahydroxylactone (5), cabralealactone (6), hollongdione (8) and dammaradienone (9), the coumarins scoparone and scopoletin, and vanillic acid were also isolated from the wood and leaves of this plant. Compounds 1-7 displayed antimycobacterial activity against Mycobacterium tuberculosis. Compounds 1, 4, 5 and 6 were weakly cytotoxic to a breast cancer (BC) cell line; whereas, compound 6 was moderately active against a small-cell lung cancer (NCI-H187) cell line.
A New Sesquiterpene and Other Terpenoid Constituents ofChisocheton penduliflorus
Jarinporn Phongmaykin,Takuya Kumamoto,Rutt Suttisri,Tsutomu Ishikawa,Ekarin Saifah 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
A new aromadendrane sesquiterpene, allo-aromadendrane-10α, 14-diol (3), was isolated from Chisocheton penduliflorus (Meliaceae), along with two known sesquiterpenes: allo-aromadendrane- 10 β, 14-diol (2) and allo-aromadendrane-10 β, 13, 14-triol (7). Six dammarane triterpenoids, including cabraleadiol (1), eichlerialactone (4), cabraleahydroxylactone (5), cabralealactone (6), hollongdione (8) and dammaradienone (9), the coumarins scoparone and scopoletin, and vanillic acid were also isolated from the wood and leaves of this plant. Compounds 1-7 displayed antimycobacterial activity against Mycobacterium tuberculosis. Compounds 1, 4, 5 and 6 were weakly cytotoxic to a breast cancer (BC) cell line; whereas, compound 6 was moderately active against a small-cell lung cancer (NCI-H187) cell line.
Cytotoxic C-Benzylated Chalcone and Other Constituents of Ellipeiopsis
Lalita Wirasathien,Thitima Pengsuparp,Masataka Moriyasu,Kazuko Kawanishi,Rutt Suttisri 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.6
A new natural C-benzylated chalcone, 2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6¢-methoxychalcone (2), along with two other flavonoids, tiliroside and kaempferol 3-O-rutinoside, and an oxoaporphine alkaloid, lanuginosine were isolated from the aerial parts of Ellipeiopsis cherrevensis (Annonaceae). Two known polyoxygenated cyclohexene derivatives, ferrudiol and zeylenol, and a new analog, ellipeiopsol D, were also isolated. The chalcone 2 exhibited cytotoxic activity against human small-cell lung-cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines with IC50 values of 1.40, 5.31 and 13.92 µg/mL, respectively. This compound also showed antimalarial activity against Plasmodium falciparum with an IC50 value of 7.1 µg/mL as well as antimicrobacterial activity against Mycobacterium tuberculosis with a MIC of 25 mg/mL.
Cytotoxic C-Benzylated Chalcone and Other Constituents of Ellipeiopsis cherrevensis
Wirasathien, Lalita,Pengsuparp, Thitima,Moriyasu, Masataka,Kawanishi, Kazuko,Suttisri, Rutt The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.6
A new natural C-benzylated chalcone, $2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6{\c}-methoxychalcone$ (2), along with two other flavonoids, tiliroside and kaempferol 3-O-rutinoside, and an oxoaporphine alkaloid, lanuginosine were isolated from the aerial parts of Ellipeiopsis cherrevensis (Annonaceae). Two known polyoxygenated cyclohexene derivatives, ferrudiol and zeylenol, and a new analog, ellipeiopsol D, were also isolated. The chalcone 2 exhibited cytotoxic activity against human small-cell lung-cancer (NCl-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines with $IC_{50}$ values of 1.40, 5.31 and $13.92\;{\mu}g/mL$, respectively. This compound also showed antimalarial activity against Plasmodium falciparum with an $IC_{50}$ value of $7.1\;{\mu}g/mL$ as well as antimicrobacterial activity against Mycobacterium tuberculosis with a MIC of 25 mg/mL.