http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Susmita Aryal (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Engineered iron oxide nanoparticles to improve regenerative effects of mesenchymal stem cells
Wan Su Yun,Susmita Aryal,Ye Ji Ahn,서영준,Jaehong Key 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.2
Mesenchymal stem cells (MSCs) based therapies are a major fi eld of regenerative medicine. However, the success of MSCtherapy relies on the effi ciency of its delivery and retention, diff erentiation, and secreting paracrine factors at the targetsites. Recent studies show that superparamagnetic iron oxide nanoparticles (SPIONs) modulate the regenerative eff ects ofMSCs. After interacting with the cell membrane of MSCs, SPIONs can enter the cells via the endocytic pathway. The physicochemicalproperties of nanoparticles, including size, surface charge (zeta-potential), and surface ligand, infl uence theirinteractions with MSC, such as cellular uptake, cytotoxicity, homing factors, and regenerative related factors (VEGF, TGF-β1). Therefore, in-depth knowledge of the physicochemical properties of SPIONs might be a promising lead in regenerativeand anti-infl ammation research using SPIONs mediated MSCs. In this review, recent research on SPIONs with MSCs andthe various designs of SPIONs are examined and summarized.
-
Song-Yi Kim,Wan Su Yun,Susmita Aryal,Woo Cheol Kim,Suk-bae Moon,Jaehong Key,Seongyup Kim 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.3
The aim of this study is to investigate the potential impact of catheterization on intimal hyperplasia and explore the efficacyof Paclitaxel loaded PLGA nanoparticles (PTX-NPs) in preventing stenosis at the site of venous injury. Under general anesthesia,Central Venous Catheters were inserted into the rat’s right internal jugular veins (IJV) using the cut-down technique. Twenty bare catheters (C) and twenty PTX-NPs coated catheters (P) were assigned to one of four groups (C2, C4, P2, or P4)based on catheter type and expected survival time. 2 or 4 weeks after surgery, IJVs were completely harvested by formalinfixation and gelatin infusion and slides were stained with H&E (Haematoxylin and Eosin) and Masson's technique. The P2(Paclitaxel coating, 2 weeks) group showed the most proliferation among the four groups and the P4 (Paclitaxel coating,4 weeks) showed a tendency to decrease proliferation. Additionally, the lumen size in the P4 group was about 6% smaller thanin the P2 group, and there was a lower prevalence of stenotic grade in the P4 group. Our study suggests that PTX-NPs coatedcatheters may be effective in preventing venous stenosis if the intended usage is prolonged, rather than for a short-term period.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
