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Distribution of Nitric Oxide Synthase Isoforms in Perioral Exocrine Glands in Rats
Jeong, Jongcheol,Kim, Sunhun,Kim, Hyunjin,Kim, Minseok,Koh, Jeongtae,Lee, Kiheon,Kim, Wonjae,Oh, Wonmann,Lee, Eunjoo,Ryu, Sunyoul Korean Academy of Oral Biology and the UCLA Dental 2001 International Journal of Oral Biology Vol.26 No.1
Endogenous nitric oxide (NO), synthesized by NO synthase (NOS), has been reported to play certain roles in exocrine gland secretion. Little has been found, however, on the distribution of NOS isoforms in perioral exocrine glands and their innervating ganglia. Monoclonal mouse anti-endothelial NOS and anti-neuronal NOS were used as primary antibodies for immunohistochemistry. Neuronal NOS(nNOS) immunoreactivity was strongly demonstrated in the submandibular ganglion an postganglionic fibers in the submandibular and minor salivary glands in the tongue and in the lacrimal gland. nNOS was also moderately stained in the myoepithelial cells and excretory ducts of the major salivary glands with the ducts in the parotid gland staining weakest. The reactivity was weak in the sebaceous gland and barely visible in the superior cervical ganglion, trigeminal ganglion, excretory ducts of the minor salivary glands and acini of all the salivary glands. Strong endothelial NOS(eNOS) immunoreactivity was observed in the vascular endothelial cells, excretory ducts of the major salivary glands and the lacrimal gland. The eNOS immunoreactivity was moderate in the myoepithelial cells in the major salivary glands. In contrast, very weak reactivity was seen in some acini of the major salivary glands and the sebaceous gland, and no reactivity was present in the ganglia and nerve fibers. These results suggest that eNOS-synthesized NO is implicated in the regulation of blood flow and secretion in perioral exocrine glands, whereas nNOS-synthesized NO is involved in th regulation of secretion in the perioral exocrine glands and may act as a neurotransmitter in their innervating parasympathetic ganglia.
Wideband VHF and UHF RF Front-End Receiver for DVB-H Application
Joonhong Park,Sunyoul Kim,Minhye Ho,Donghyun Baek 대한전기학회 2012 Journal of Electrical Engineering & Technology Vol.7 No.1
This paper presents a wideband and low-noise direct conversion front-end receiver supporting VHF and UHFbands simultaneously. The receiver iscomposed of a low-noise amplifier (LNA), a down conversion quadrature mixer, and a frequency divider by 2. The cascode configuration with the resistor feedback is exploited in the LNA to achieve a wide operating bandwidth. Four gainstep modesare employed using a switched resistor bank and a capacitor bank in the signal path to cope with wide dynamic input power range. The verticalbipolar junction transistors are used as the switching elements in the mixer to reduce 1/f noise corner frequency. The proposed front-end receiver fabricated in 0.18 μm CMOS technology shows very low minimum noise figureof 1.8 dB and third order input intercept pointof -12dBm inthe high-gain mode of 26.5 dBmeasured at 500 MHz.The proposed receiverconsumeslow current of 20 mA from a 1.8 V power supply.