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RISS 인기검색어
- 검색키워드
- 저자 : Suneel Pandey (검색결과 3 건)
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Mucoadhesive buccal tablets of domperidone: formulation evaluation and effects of process variables
Suneel Lakshminarayan Pandey,Nilesh Tikaram Hingawe,Ujjalkumar Das,Arun Triyambak Patil 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.2
The aim of the present work was to develop andevaluate buccal adhesive tablets of domperidone and studythe effect of diluents. Tablets were prepared by direct compressionmethod using different polymer and excipientscombinations. Formulations batches were evaluated forphysical parameter, swelling studies, bioadhesion studiesand in vitro drug release. Formulation batch F2 was mostpromising composition of 1:5 ratio of HPMC K4 M/Sodiumalginate. Effect of formulation variables such as diluents i.e. lactose (water soluble) and di-calcium phosphate (DCP)(water insoluble) studied on swelling index, bioadhesiveperformance and in vitro drug release. Bioadhesive force wasdrastically decreased in presence of DCP; it was concludedthat DCP more significantly affected the swelling index thandid lactose. Both Lactose and DCP similarly affect the bioadhesivestrength of buccal adhesive tablets. Dissolutionprofiles have shown non-fickian drug release mechanism,which indicated that the drug was released by diffusion anderosion mechanism. Thereby buccal adhesive tablets offer apromising strategy for drug delivery of domperidone.
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Suneel Pandey,Ujjalkumar Das,Arun Patil 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.4
Periodontal disease comprises a group ofinflammatory conditions of periodontal tissues with commonetiologic agent (bacteria) in the form of dental plaque. The objective of this research was to prepare a water-in-oiltype microemulsion comprising metronidazole and equateits potency towards the effective treatment of periodontitis. A pseudo ternary phase diagram for microemulsioninvestigated using quaternary system containing water/captex 500/ tween 80/acconon CC6. The microemulsionwas preferred from the microemulsion area on the phasediagram. Stable water-in-oil type metronidazole microemulsionwas prepared successfully using the quaternarysystem of water/captex 500/ tween 80/acconon CC6 at 4:1ratio having droplet size in the range of 81 ± 12.91 to196 ± 10.73 nm, conductivity 50.6 ± 0.8 to 330.7 ±1.1 ls/cm. In-vitro drug release, in vitro and ex vivoantimicrobial activities by agar well diffusion were investigated. Metronidazole Microemulsion loaded hydrogelformulations (F9 and F10) were found to be optimized formaximum release and antimicrobial activity in terms ofzone of inhibition. The in vitro release evidenced thatmetronidazole microemulsion loaded hydrogel release ratewas maximum as compared to other plain metronidazolegels. Stability study proved that microemulsion persistedstable for at least 6 months; with no changes in clarity,characteristic properties, and no sign of crystallization ofmetronidazole. In ex vivo evaluation, microemulsion basedhydrogels were effective against the microbial flora of thehuman oral cavity suffering from periodontitis. The systemwas found to be appropriate for application and moreeffective in reducing the clinical symptoms of periodontitis.
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On the secrecy performance of RIS-enabled wireless communications over Nakagami-m fading channels
Ashutosh K. Yadav,Suneel Yadav,Anshul Pandey,Adão Silva 한국통신학회 2023 ICT Express Vol.9 No.3
This paper examines the secrecy performance of reconfigurable intelligent surface aided wireless communication systems. Specifically, we derive the secrecy outage probability (SOP), intercept probability, probability of non-zero secrecy capacity, and ergodic secrecy capacity (ESC) expressions over Nakagami-m fading channels. We further evaluate the asymptotic SOP expressions to get some insights into the secrecy diversity order under two scenarios of interest; (1) when the signal-to-noise ratio approaches infinity, and (2) when the main-to-eavesdropper ratio tends to infinity. Also, we analytically show the effect of reflecting element density on the ESC performance. The numerical and simulation studies verify our analytical findings.
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