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RISS 인기검색어
- 검색키워드
- 저자 : Sumit RAJPUT (검색결과 4 건)
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( Sumit Rajput ),( P Ashok ),( A Joshi ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Asparagus racemosus is a widely found medicinal plant in tropical and subtropical parts of India. Our objective was to investigate effects of Asparagus racemosu root extract (ARRE) on constipation, liver dysfunctions and defence of red blood cells in type 2 diabetic patients. Methods: A total number of 100 subjects were selected with the age ranging from 45 to 60 years. Among them, 50 diagnosed type 2 diabetes individuals were included in the Group A and 50 apparently healthy individuals were selected as Group B for comparison. ARRE was prepared in hot water and orally administered to type 2 diabetic patients with constipation. This treatment was thrice a week in 1<sup>st</sup> month, twice in a week in corresponding 2<sup>nd</sup> and 3<sup>rd</sup> months and once in a week from 4<sup>th</sup> to 6<sup>th</sup> months. The defensive enzyme, glutathione peroxidase, superoxide dismutase, catalase and fasting blood sugar, hemoglobin A1c, apolipoprotein B, apolipoprotein A-I, and malondialdehyde were measured in the red blood cells. The liver function test was performed by measuring hepatic enzymes (Aspartate amino transferase, alanine amino transferase) and lipid profile levels. Results: ARRE supplementation significantly reduced the levels of fasting blood sugar, serum hepatic enzymes, hemoglobin A1c, apolipoprotein B, apolipoprotein B/apolipoprotein A-I and malondialdehyde in ARRE group in comparison to baseline, as well as control group, while it increased the level of apolipoprotein A-I (P<0.05). The diabetic patients were found to be altered lipid profile with vulnerable to skin infection particularly in the pelvic regions, backside, legs, etc. which were reversed to normal after six months of ARRE treatments. The stools quality also changed to normal. The antioxidant enzymes decreased in red blood cells of diabetics by 20-30%, normalized after six months of treatment with ARRE extract. There was also normalize hepatic enzymes activity with ARRE treatment to diabetic patients. Conclusions: ARRE treatment to diabetic patients not only normalize the defense of red blood cells but also corrects skin infection, liver disorder, neurological disorder and physiological disorder. The findings evidently suggest the hepatoprotective properties of ARRE in diabetic patients.
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( Sumit Rajput ),( P Ashok ),( A Joshi ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Diabetes mellitus is an endocrine disease of multiple aetiologies in insulin secretion. A deficiency in insulin results in hyperglycemia with metabolic disturbances of biomolecules. Moringa oleifera is endemic in the tropics with a variety of ethnomedicinal importance. The leaf of this plant has been reported to possess antioxidant and medicinal properties that may be helpful in the treatment and management of diabetes and its associated complications. This study evaluated the antidiabetic potentials of flavonoid-rich aqueous fraction of methanolic extract of Moringa oleifera (MOE) on the pancreatic β-cells of streptozotocin (STZ) and high-fat diet induced type 2 diabetes mellitus (T2DM) in rats. Methods: Diabetes was induced intraperitoneally in rats by a single dose of streptozotocin (55 mg/kg) and treated with MOE (50, 100, 200 mg/kg b.wt) for six weeks. The rats were randomly divided into normal (NC), T2DM, metformin (Met), low, middle (Mid), and high (Hig) does of MOE groups. After six weeks of continuous administration of MOE, the serum indices and tissue protein expression were determined, and the pathological changes in liver and pancreas tissues were observed. Animals were sacrificed; the splenic portion of their pancreas and serum were evaluated for histopathological and biochemical parameters respectively. Results: The results showed that compared with the type 2 diabetes mellitus group, the fasting blood glucose (FBG), total cholesterol (TC), and triglyceride (TG) levels in the serum of rats in the dose dependent MOE treatment groups were significantly (P<0.05). decreased, while superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) levels were noticeably increased. The expression of Fas ligand (FasL), cytochrome C (Cyt-c), and caspase-3 in pancreatic tissue was obviously decreased, and the pathological damage to the liver, kidney, and pancreas was improved. These indicate that MOE can reduce oxidative stress in rats with diabetes mellitus by improving blood lipid metabolism and enhancing their antioxidant capacity, thereby regulating the mitochondrial apoptotic pathway to inhibitβ-cell apoptosis and improve β-cell function. The morphology of the pancreas of MOE-treated diabetic rats revealed remarkable improvements in the islet of Langerhans. Stereological studies also revealed that MOE-treatment remarkably improved volume of the pancreatic islets and the numerical density of β-cell (number of β-cells per unit area of islet) depleted by STZ diabetes. Conclusions: The study concluded that possible antidiabetic mechanism of MOE in STZ diabetes is through induction of β-cell regeneration and its strong antioxidant potential.
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