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An Efficient Compression Algorithm for Forthcoming New Species
Subhankar Roy,Sudip Mondal,Sunirmal Khatua,Moumita Biswas 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.11
Genomic repositories gradually increase individual and reference sequences, which shares long identical and near-identical strings of nucleotides. In this paper a lossless DNA data compression technique called Optimized Base Repeat Length DNA Compression (OBRLDNAComp) has been proposed, based upon redundancy of DNA sequences. For easy storage, retrieval time reducing and to find similarity within and between sequences compression is mandatory. OBRLDNAComp searches long identical and near-identical strings of nucleotides which are overlooked by other DNA specific compression algorithms. This technique is an optimal solution of longest possible exact repeat benefits towards compression ratio. It scans a sequence horizontally from left to right to find statistic of repeats then follow substitution technique to compress those repeats. The algorithm is straightforward and does not need any external reference file; it scans the individual file for compression and decompression. The achieved compression ratio 1.673 bpb outperforms many non-reference based compression methods.
Ashis Kumar Roy,Apu Kumar Saha,R. Ponalagusamy,Sudip Debnath 한국유변학회 2020 Korea-Australia rheology journal Vol.32 No.4
The mathematical model of hydrodynamic dispersion through a porous medium is developed in the presence of transversely applied magnetic fields and axial harmonic pressure gradient. The solute introduce into the flow is experienced a first-order chemical reaction with flowing liquid. The dispersion coefficient is numerically determined using Aris’s moment equation of solute concentration. The numerical technique employed here is a finite difference implicit scheme. Dispersion coefficient behavior with Darcy number, Hartmann number and bulk flow reaction parameter is investigated. This study highlighted that the dependency of Hartmann number and Darcy number on dispersion shows different natures in different ranges of these parameters.
Swati Dasgupta,Ujjal K Ray,Arpita Ghosh Mitra,Deboshree M. Bhattacharyya,Ashis Mukhopadhyay,Priyabrata Das,Sudeshna Gangopadhyay,Sudip Roy,Soma Mukhopadhyay 대한혈액학회 2017 Blood Research Vol.51 No.2
Background: Philadelphia chromosome, a hallmark of chronic myeloid leukemia (CML), plays a key role in disease pathogenesis. It reflects a balanced reciprocal translocation between long arms of chromosomes 9 and 22 involving BCR and ABL1 genes, respectively. An accurate and reliable detection of BCR-ABL fusion gene is necessary for the diagnosis and monitor-ing of CML. Previously, many technologies, most of which are laborious and time consum-ing, have been developed to detect BCR-ABL chimeric gene or chromosome. Methods: A new flow cytometric immunobead assay was used for detection of BCR-ABL fusion pro-teins and applicability, sensitivity, reliability, efficacy and rapidity of this method was evaluated. Results: From February 2009 to January 2014, a total 648 CML patients were investigated for the status of BCR-ABL1 protein. Among them, 83 patients were enrolled for comparative study of BCR-ABL1 positivity by three routinely used procedures like karyotyping, and quantita-tive real time PCR (RT-PCR) as well as immunobead flow cytometry assay. BCR-ABL protein analysis was found consistent, more sensitive (17% greater sensitivity) and reliable than the conventional cytogenetics, as flow cytometry showed 95% concordance rate to RT-PCR. Conclusion: BCR-ABL fusion protein assay using a new flow cytometric immunobead might be useful in the diagnosis and monitoring CML patients.
Swati Dasgupta,Ujjal K Ray,Arpita Ghosh Mitra,Deboshree M. Bhattacharyya,Ashis Mukhopadhyay,Priyabrata Das,Sudeshna Gangopadhyay,Sudip Roy,Soma Mukhopadhyay 대한혈액학회 2017 Blood Research Vol.52 No.2
Background: Philadelphia chromosome, a hallmark of chronic myeloid leukemia (CML), plays a key role in disease pathogenesis. It reflects a balanced reciprocal translocation between long arms of chromosomes 9 and 22 involving BCR and ABL1 genes, respectively. An accurate and reliable detection of BCR-ABL fusion gene is necessary for the diagnosis and monitor-ing of CML. Previously, many technologies, most of which are laborious and time consum-ing, have been developed to detect BCR-ABL chimeric gene or chromosome. Methods: A new flow cytometric immunobead assay was used for detection of BCR-ABL fusion pro-teins and applicability, sensitivity, reliability, efficacy and rapidity of this method was evaluated. Results: From February 2009 to January 2014, a total 648 CML patients were investigated for the status of BCR-ABL1 protein. Among them, 83 patients were enrolled for comparative study of BCR-ABL1 positivity by three routinely used procedures like karyotyping, and quantita-tive real time PCR (RT-PCR) as well as immunobead flow cytometry assay. BCR-ABL protein analysis was found consistent, more sensitive (17% greater sensitivity) and reliable than the conventional cytogenetics, as flow cytometry showed 95% concordance rate to RT-PCR. Conclusion: BCR-ABL fusion protein assay using a new flow cytometric immunobead might be useful in the diagnosis and monitoring CML patients.