http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Paramagnetic Gd<sup>3+</sup> labeled red blood cells for magnetic resonance angiography
Aryal, S.,Stigliano, C.,Key, J.,Ramirez, M.,Anderson, J.,Karmonik, C.,Fung, S.,Decuzzi, P. IPC Science and Technology Press 2016 Biomaterials Vol.98 No.-
<P>Despite significant advances in contrast enhanced-magnetic resonance angiography, the lack of truly blood-pool agents with long circulating property is limiting the clinical impact of this imaging technique. The terminal half-life for blood elimination of most small molecular weight gadolinium (Gd) based extracellular fluid agents is about 1.5 h when administered intravenously to subjects with normal renal function. The small size of these extracellular fluid agents does not prevent them from extravasating, especially from damaged vessels which are generally hyperpermeable. Therefore, the development of novel, clinically relevant blood pool contrast agents is critically needed to improve outcomes in the prevention, detection, and treatment of vascular diseases. We have demonstrated the fusion strategies in which the Gd-liposome without any stealth property radically fuses with red blood cells (RBCs) forming MR glowing Gd-RBC with the order of magnitude enhancements in circulation half-life (t(1/2) = 50 h) and r(1) relaxivity (r(1) = 19.0 mM(-1) s(-1)) of Gd. The in vivo contrast enhancement of Gd-RBC was studied by using 3T clinical MR scanner for extended period of time, which clearly visualized the abdominal aorta. In summary, the vascular delivery of blood pool agents may benefit from carriage by RBCs because it naturally stays within the vascular lumen. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Cervadoro, Antonio,Cho, Minjung,Key, Jaehong,Cooper, Christy,Stigliano, Cinzia,Aryal, Santosh,Brazdeikis, Audrius,Leary, James F.,Decuzzi, Paolo American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.15
<P/><P>Iron oxide nanoparticles (IOs) are intrinsically theranostic agents that could be used for magnetic resonance imaging (MRI) and local hyperthermia or tissue thermal ablation. Yet, effective hyperthermia and high MR contrast have not been demonstrated within the same nanoparticle configuration. Here, magnetic nanoconstructs are obtained by confining multiple, ∼ 20 nm nanocubes (NCs) within a deoxy-chitosan core. The resulting nanoconstructs—magnetic nanoflakes (MNFs)—exhibit a hydrodynamic diameter of 156 ± 3.6 nm, with a polydispersity index of ∼0.2, and are stable in PBS up to 7 days. Upon exposure to an alternating magnetic field of 512 kHz and 10 kA m<SUP>–1</SUP>, MNFs provide a specific absorption rate (SAR) of ∼75 W g<SUB>Fe</SUB><SUP>–1</SUP>, which is 4–15 times larger than that measured for conventional IOs. Moreover, the same nanoconstructs provide a remarkably high transverse relaxivity of ∼500 (mM s)<SUP>−1</SUP>, at 1.41T. MNFs represent a first step toward the realization of nanoconstructs with superior relaxometric and ablation properties for more effective theranostics.</P>