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RISS 인기검색어
- 검색키워드
- 저자 : Stengl, Gabriele (검색결과 2 건)
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Atmospheric plasma sprayed (APS) coatings of $Al_2O_3-TiO_2$ system for photocatalytic application
Stengl, V.,Ageorges, H.,Ctibor, P.,Murafa, N. Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.5
The goal of this study is to examine the photocatalytic ability of coatings produced by atmospheric plasma spraying (APS). The plasma gun used is a common gas-stabilized plasma gun (GSP) working with a d.c. current and a mixture of argon and hydrogen as plasma-forming gas. The $TiO_2$ powders are particles of about 100 nm which were agglomerated to a mean size of about 55 ${\mu}m$, suitable for spraying. Composition of the commercial powder is 13 wt% of $TiO_2$ in $Al_2O_3$, whereas also in-house prepared powder with the same nominal composition but with agglomerated $TiO_2$ and conventional fused and crushed $Al_2O_3$ was sprayed. The feedstock materials used for this purpose are $\alpha$-alumina and anatase titanium dioxide. The coatings are analyzed by scanning electron microscopy (SEM), energy dispersion probe (EDS) and X-ray diffraction. Photocatalytic degradation of acetone is quantified for various coatings. All plasma sprayed coatings show a lamellar structure on cross section, as typical for this process. Anatase titania from feedstock powder is converted into rutile titania and $\alpha$-alumina partly to $\gamma$-alumina. Coatings are proven to catalyse the acetone decomposition when irradiated by UV rays.
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Stat5 is indispensable for the maintenance of <i>bcr/abl</i> -positive leukaemia
Hoelbl, Andrea,Schuster, Christian,Kovacic, Boris,Zhu, Bingmei,Wickre, Mark,Hoelzl, Maria A,Fajmann, Sabine,Grebien, Florian,Warsch, Wolfgang,Stengl, Gabriele,Hennighausen, Lothar,Poli, Valeria,Beug, WILEY-VCH Verlag 2010 EMBO molecular medicine Vol.2 No.3
<P>Tumourigenesis caused by the Bcr/Abl oncoprotein is a multi-step process proceeding from initial to tumour-maintaining events and finally results in a complex tumour-supporting network. A key to successful cancer therapy is the identification of critical functional nodes in an oncogenic network required for disease maintenance. So far, the transcription factors Stat3 and Stat5a/b have been implicated in <I>bcr/abl</I>-induced initial transformation. However, to qualify as a potential drug target, a signalling pathway must be required for the maintenance of the leukaemic state. Data on the roles of Stat3 or Stat5a/b in leukaemia maintenance are elusive. Here, we show that both, Stat3 and Stat5 are necessary for initial transformation. However, Stat5- but not Stat3-deletion induces G<SUB>0</SUB>/G<SUB>1</SUB> cell cycle arrest and apoptosis of imatinib-sensitive and imatinib-resistant stable leukaemic cells <I>in vitro</I>. Accordingly, Stat5-abrogation led to effective elimination of myeloid and lymphoid leukaemia maintenance <I>in vivo</I>. Hence, we identified Stat5 as a vulnerable point in the oncogenic network downstream of Bcr/Abl representing a case of non-oncogene addiction (NOA).</P>
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