http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Steinsson, K. (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Hanly, J. G.,Urowitz, M. B.,Siannis, F.,Farewell, V.,Gordon, C.,Bae, S. C.,Isenberg, D.,Dooley, M. A.,Clarke, A.,Bernatsky, S.,Gladman, D.,Fortin, P. R.,Manzi, S.,Steinsson, K.,Bruce, I. N.,Ginzler, E Wiley Subscription Services, Inc., A Wiley Company 2008 Vol.58 No.3
<B>Objective</B><P>To examine, in an inception cohort of systemic lupus erythematosus (SLE) patients, the association between neuropsychiatric (NP) events and anti–ribosomal P (anti-P), antiphospholipid (lupus anticoagulant [LAC], anticardiolipin), anti–β2-glycoprotein I, and anti–NR2 glutamate receptor antibodies.</P><B>Methods</B><P>NP events were identified using the American College of Rheumatology case definitions and clustered into central/peripheral and diffuse/focal events. Attribution of NP events to SLE was determined using decision rules of differing stringency. Autoantibodies were measured without knowledge of NP events or their attribution.</P><B>Results</B><P>Four hundred twelve patients were studied (87.4% female; mean ± SD age 34.9 ± 13.5 years, mean ± SD disease duration 5.0 ± 4.2 months). There were 214 NP events in 133 patients (32.3%). The proportion of NP events attributed to SLE varied from 15% to 36%. There was no association between autoantibodies and NP events overall. However, the frequency of anti-P antibodies in patients with central NP events attributed to SLE was 4 of 20 (20%), versus 3 of 107 (2.8%) in patients with other NP events and 24 of 279 (8.6%) in those with no NP events (P = 0.04). Among patients with diffuse NP events, 3 of 11 had anti-P antibodies (27%), compared with 4 of 111 patients with other NP events (3.6%) and 24 of 279 of those with no NP events (8.6%) (P = 0.02). Specific clinical–serologic associations were found between anti-P and psychosis attributed to SLE (P = 0.02) and between LAC and cerebrovascular disease attributed to SLE (P = 0.038). There was no significant association between other autoantibodies and NP events.</P><B>Conclusion</B><P>Clinically distinct NP events attributed to SLE and occurring around the time of diagnosis were found to be associated with anti-P antibodies and LAC. This suggests that there are different autoimmune pathogenetic mechanisms, although low sensitivity limits the clinical application of testing for these antibodies.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
