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( Joshua T. Steere ),( Michael C. Sobieraj ),( Christopher J. Defrancesco ),( Craig L. Israelite ),( Charles L. Nelson ),( Atul F. Kamath ) 대한슬관절학회 2018 대한슬관절학회지 Vol.30 No.3
Purpose: Obesity is a risk factor for aseptic loosening after total knee arthroplasty (TKA). Prophylactic use of tibial stems may enhance tibial fixation in obese patients. The aim of this study was to determine whether a tibial stem extension decreases rates of early failure in obese patients. Materials and Methods: This study included 178 consecutive primary TKAs (143 patients) with a body mass index ≥35 kg/m<sup>2</sup>. Fifty TKAs were performed with the use of a 30 mm tibial stem extension, and 128 TKAs were performed with a standard tibial component. Patients with twoyear clinical follow-up were included. The primary outcome was revision for aseptic loosening. Secondary outcomes were all-cause revision and radiolucent lines (RLLs) on radiographs. Results: Average follow-up was 34 months (range, 24 to 46 months). No failures for aseptic loosening occurred. The occurrence of secondary procedures was not significantly different between groups. Quantification of RLLs revealed no difference between groups. Conclusions: At early follow-up, no difference was measured in revision rates, need for subsequent procedures, or RLLs between groups.
EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.
Xu, Xiangbin,Woo, Chang-Hoon,Steere, Rachel R,Lee, Byung Cheol,Huang, Yuxian,Wu, Jing,Pang, Jinjiang,Lim, Jae Hyang,Xu, Haidong,Zhang, Wenhong,Konduru, Anuhya S,Yan, Chen,Cheeseman, Michael T,Brown, S Williams Wilkins 2012 JOURNAL OF IMMUNOLOGY Vol.188 No.12
<P>Inflammation is a hallmark of many important human diseases. Appropriate inflammation is critical for host defense; however, an overactive response is detrimental to the host. Thus, inflammation must be tightly regulated. The molecular mechanisms underlying the tight regulation of inflammation remain largely unknown. Ecotropic viral integration site 1 (EVI1), a proto-oncogene and zinc finger transcription factor, plays important roles in normal development and leukemogenesis. However, its role in regulating NF-κB-dependent inflammation remains unknown. In this article, we show that EVI1 negatively regulates nontypeable Haemophilus influenzae- and TNF-α-induced NF-κB-dependent inflammation in vitro and in vivo. EVI1 directly binds to the NF-κB p65 subunit and inhibits its acetylation at lysine 310, thereby inhibiting its DNA-binding activity. Moreover, expression of EVI1 itself is induced by nontypeable Haemophilus influenzae and TNF-α in an NF-κB-dependent manner, thereby unveiling a novel inducible negative feedback loop to tightly control NF-κB-dependent inflammation. Thus, our study provides important insights into the novel role for EVI1 in negatively regulating NF-κB-dependent inflammation, and it may also shed light on the future development of novel anti-inflammatory strategies.</P>
Round-up of GHSA Steering Group and Action Packages in 2015
GHSA Steering Group Secretariat,GHSA Preparation Task Force Team 질병관리본부 2015 Osong Public Health and Research Persptectives Vol.6 No.-
All Global Health Security Agenda (GHSA) Steering Group Members remain strongly committed to accelerating measurable progress and implementing concrete commitments toward a world safe and secure from infectious disease threats, recognizing the devastation of the Ebola epidemic and the clear interdependence of health in the 21st century. All GHSA Steering Group members reinforced that GHSA is supportive of International Health Regulations implementation, as well as components of other global health security frameworks such as the World Organization for Animal Health Performance of Veterinary Services pathway. The GHSA will continue to focus on multilateral engagement. The GHSA Steering Group is committed to engaging non-state actors and agreed to discuss next steps toward engaging the private sector.
Korean Industry in the New Millennium : The Challenges Ahead
Steers, Richard M.,Ungson, Gerardo R. THE MANAGEMENT RESEARCH CENTRE YONSEI UNIVERSITY 2000 SANGNAM FORUM Vol.- No.-
Factors leading up to the 1997 financial crisis and effects of the IMF intervention are reviewed as a basis for discussing future economic and managerial challenges facing Korean firms. It is argued that Korean firms face six principal challenges, including reducing excessive economic concentration, increasing concern for public welfare, increasing corporate specialization, fostering an independent banking system, corporate restructuring, and greater financial transparency. At the same time, it is suggested that the Korean government can do more to resource development, support for small and medium-sized enterprise, increased support for technological innovation, and continued efforts to achieve political stability in the region. It is suggested that caution is in order in any attempt to apply western theories or mandates to the analysis and resolution of complex political and economic problems in other parts of the world, including Korea.