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Simpson, Michael F.,Sachdev, Prateek Korean Nuclear Society 2008 Nuclear Engineering and Technology Vol.40 No.3
The results of process development for the blending of waste salt from the electrorefining of spent fuel with zeolite-A are presented. This blending is a key step in the ceramic waste process being used for treatment of EBR-II spent fuel and is accomplished using a high-temperature v-blender. A labscale system was used with non-radioactive surrogate salts to determine optimal particle size distributions and time at temperature. An engineering-scale system was then installed in the Hot Fuel Examination Facility hot cell and used to demonstrate blending of actual electrorefiner salt with zeolite. In those tests, it was shown that the results are still favorable with actinide-loaded salt and that batch size of this v-blender could be increased to a level consistent with efficient production operations for EBR-II spent fuel treatment. One technical challenge that remains for this technology is to mitigate the problem of material retention in the v-blender due to formation of caked patches of salt/zeolite on the inner v-blender walls.
SELECTIVE REDUCTION OF ACTIVE METAL CHLORIDES FROM MOLTEN LiCl-KCl USING LITHIUM DRAWDOWN
Simpson, Michael F.,Yoo, Tae-Sic,Labrier, Daniel,Lineberry, Michael,Shaltry, Michael,Phongikaroon, Supathorn Korean Nuclear Society 2012 Nuclear Engineering and Technology Vol.44 No.7
In support of optimizing electrorefining technology for treating spent nuclear fuel, lithium drawdown has been investigated for separating actinides from molten salt electrolyte. Drawdown reaction selectivity is a major issue that requires investigation, since the goal is to remove actinides while leaving the fission products and other components in the salt. A series of lithium drawdown tests with surrogate fission product chlorides was run to obtain selectivity data with non-radioactive salts, develop a predictive model, and draw conclusions about the viability of using this process with actinide-loaded salt. Results of tests with CsCl, $LaCl_3$, $CeCl_3$, and $NdCl_3$ are reported here. Equilibrium was typically achieved in less than 10 hours of contact between lithium metal and molten salt under well-stirred conditions. Maintaining low oxygen and water impurity concentrations (<10 ppm) in the atmosphere was observed to be critical to minimize side reactions and maintain stable salt compositions. An equilibrium model has been formulated and fit to the experimental data. Good fits to the data were achieved. Based on analysis and results obtained to date, it is concluded that clean separation between minor actinides and lanthanides will be difficult to achieve using lithium drawdown.
Simpson, David C.,Ahn, Seonghee,Pasa-Tolic, Ljiljana,Bogdanov, Bogdan,Mottaz, Heather M.,Vilkov, Andrey N.,Anderson, Gordon A.,Lipton, Mary S.,Smith, Richard D. WILEY-VCH Verlag 2006 Electrophoresis Vol.27 No.13
<P>Bottom-up proteomics (analyzing peptides that result from protein digestion) has demonstrated capability for broad proteome coverage and good throughput. However, due to incomplete sequence coverage, this approach is not ideally suited to the study of modified proteins. The modification complement of a protein can best be elucidated by analyzing the intact protein. 2-DE, typically coupled with the analysis of peptides that result from in-gel digestion, is the most frequently applied protein separation technique in MS-based proteomics. As an alternative, numerous column-based liquid phase techniques, which are generally more amenable to automation, are being investigated. In this work, the combination of size-exclusion chromatography (SEC) fractionation with RPLC-Fourier-transform ion cyclotron resonance (FTICR)-MS is compared with the combination of RPLC fractionation with CIEF-FTICR-MS for the analysis of the Shewanella oneidensis proteome. SEC-RPLC-FTICR-MS allowed the detection of 297 proteins, as opposed to 166 using RPLC-CIEF-FTICR-MS, indicating that approaches based on LC-MS provide better coverage. However, there were significant differences in the sets of proteins detected and both approaches provide a basis for accurately quantifying changes in protein and modified protein abundances.</P>
Basis for a Minimalistic Salt Treatment Approach for Pyroprocessing Commercial Nuclear Fuel
Simpson, Michael F.,Bagri, Prashant Korean Radioactive Waste Society 2018 방사성폐기물학회지 Vol.16 No.1
A simplified flowsheet for pyroprocessing commercial spent fuel is proposed in which the only salt treatment step is actinide drawdown from electrorefiner salt. Actinide drawdown can be performed using a simple galvanic reduction process utilizing the reducing potential of gadolinium metal. Recent results of equilibrium reduction potentials for Gd, Ce, Nd, and La are summarized. A description of a recent experiment to demonstrate galvanic reduction with gadolinium is reviewed. Based on these experimental results and material balances of the flowsheet, this new variant of the pyroprocessing scheme is expected to meet the objectives of minimizing cost, maximizing processing rate, minimizing proliferation risk, and optimizing the utilization of geologic repository space.
Techniques for monitoring protein misfolding and aggregation in vitro and in living cells
Simpson Gregoire,권인찬,Jacob Irwin 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.6
Protein misfolding and aggregation have been considered important in understanding many neurodegenerative diseases and recombinant biopharmaceutical production. Various traditional and modern techniques have been utilized to monitor protein aggregation in vitro and in living cells. Fibril formation, morphology and secondary structure content of amyloidogenic proteins in vitro have been monitored by molecular probes, TEM/AFM, and CD/FTIR analyses,respectively. Protein aggregation in living cells has been qualitatively or quantitatively monitored by numerous molecular folding reporters based on either fluorescent protein or enzyme. Aggregation of a target protein is directly correlated to the changes in fluorescence or enzyme activity of the folding reporter fused to the target protein, which allows non-invasive monitoring aggregation of the target protein in living cells. Advances in the techniques used to monitor protein aggregation in vitro and in living cells have greatly facilitated the understanding of the molecular mechanism of amyloidogenic protein aggregation associated with neurodegenerative diseases, optimizing culture conditions to reduce aggregation of biopharmaceuticals expressed in living cells, and screening of small molecule libraries in the search for protein aggregation inhibitors.
Simpson Stephen-L,Singer Charlie 한국상하수도협회 1997 水道 Vol.24 No.4
County는 비용과 부지소요는 최소화하면서도 증가하는 지역적 물수요에 부합되는 높은 유량에서 정수장의 성능을 최대화해야하는 필요성에 직면해있다. 개선사항을 찾아내기 위하여 시설물에 대한 상세한 성능평가가 행해졌다. 성능평가는 여과와 소독공정이 운전방식의 조정과 함께 추가시설의 건설에 의하여 개선될 수 있음을 나타내었다. Pilot test는 실험된 여러 가지 대안들 중에서 혼화, 응집, 이중 여과방식이 입자의 제거와 정수 수질에 가장 좋은 것임을 보여주었다. 소독에 대한 분석 결과는 소독방법을 교정하고 추가적인 염소접촉시간을 주는 것이 소독의 안전성을 확보함과 동시에 정수의 소독부산물 농도를 최소한으로 하고 강화되는 규제치와 부합할 수 있는 최선의 방법이 될 것이라는 것을 보이고 있다. Pilot test는 저수두 자동역세척여과지가 1차여과지(roughing filter)로서 효과적이라는 것을 보여주었다. 실험결과는 이중여과가 최종유출수의 탁도를 평균 0.1NTU이하로 감소시키며 입자의 제거율을 3 log로 증가시킴을 나타내고 있다. 정수공정 전반에서의 입자의 제거는 여러 개의 공정의 개별적 성과의 합이 아니므로 시설물들을 건설하기 전에 정수장 전체적으로 예상되는 개선정도를 수량화하기 위하여 Pilot 실험이 필요하였다. Pilot test중에 탁도보다는 입자측정이 유량, 응집제의 주입량, 및 여타 운전조건의 변화에 훨씬 민감함을 보여주었다. 이러한 점이 입자측정이 특히 저탁도 원수에서 처리공정의 성능을 나타내 주는 적절한 추가적 수질인자라는 결론을 보강하여 주었다. 물수요에 부합하기 위하여 Freedom District 정수장을 성공적으로 개선하는 데는 원수의 수질, 단위공정의 성능, 활용가능한 수리학적 수두, 현시설의 배치, 운전양태 등과 같은 기술적 사항에 대한 고려가 필요하였다. 비록 모든 사항들이 각각 일정정도의 영향을 가지고 있으나, 상기의 모든 것들이 수질에 영향을 미쳤으며 수질의 성공적인 개선은 정수장 운전의 모든 부분을 파악할 수 있는 상세한 성능평가를 통하여 가장 잘 달성될 수 있다.