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RISS 인기검색어
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- 저자 : Silvia Oddo (검색결과 2 건)
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Silvia Oddo,Edineia Felix,Michele Mussap,Massimo Giusti 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.1
Objective: While many studies have reported that laser ablation (LA) for benign non-fuctioning thyroid nodules is efficacious in reducing nodular volume and neck symptoms, none have described changes in quality of life (QoL). The purpose of this study was to report post-LA changes in QoL in our cohort of patients. Materials and Methods: Fourteen patients with benign thyroid nodules were involved in a prospective, single-center study and underwent a single session of LA. We evaluated the following: changes in nodule volume, thyroid function, and autoimmunity; adverse events during and after LA; changes in neck discomfort by means of a visual analogic scale (VAS) at one week and 1, 3, 6, and 12 months; and changes in QoL through the 13-scale Thyroid-specific Patient Reported Outcome (ThyPRO) questionnaire at 1, 3, 6, and 12 months. ThyPRO is a validated questionnaire for thyroid diseases, which consists of 13 scales with multiple-choice answers. They investigate several aspects of life that may be impaired by goiter-related compression symptoms, by esthetic alterations and by hypo- or hyperthyroidism. Results: Nodule volume decrease was -37 ± 23%, -55 ± 22%, -53 ± 25%, -58 ± 25% (p < 0.01 vs. baseline) at the first, third, sixth, and twelfth month, respectively. No hypothyroidism or positivization of autoimmunity was observed. There were no major complications during or after LA. After LA, VAS scores improved significantly from 1 week onwards in 100% of patients, while a significant improvement was seen in the goiter symptoms score after one month, and in the general score and mean values of ThyPRO after six months. Scores on the other ThyPRO scales did not change significantly. Conclusion: Laser ablation is safe and effective in reducing nodule volume and neck symptoms; this is confirmed by improvements in the goiter scale, general score, and mean values of ThyPRO and in the VAS score.
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ÅSA BARREFELT,MOUSTAPHA HASSAN,HEBA ASEM,PETER ASPELIN,TORKEL B. BRISMAR,GAIO PARADOSSI,SILVIA MARGHERITELLI,MARYAM SAGHAFIAN,LETIZIA ODDO,MAMOUN MUHAMMED 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.6
Magnetic Resonance Imaging (MRI) is a noninvasive diagnostic method that provides informa-tion on morphological and physiological changes of the internal organs over time. Imaging andmeasurements can be repeated on the same subject, thereby reducing inter-individual variabilitye®ects and hence the number of subjects required. A potential MRI contrast agent consisting ofmicrobubbles embedded with superparamagnetic iron oxide nanoparticles (SPION) in the shell(SPION MBs) was injected intravenously into rats to determine their biodistribution andpharmacokinetics using MR imaging. Agarose phantoms containing SPION MBs were scannedusing 3 T MRI to construct a standard curve. Rats were injected with SPION MBs, free SPIONor plain MBs and scanned dynamically at 3 T using a clinical MR scanner. The relaxation rate(R2*) was studied over time as a measure of the iron oxide concentrations to enable calculation ofthe pharmacokinetic parameters. The kinetics of SPION MBs in the liver was ¯tted to a one-compartment model. Furthermore, the biological fate of SPION MBs was examined via a his-tological survey of tissue samples using Perls' Prussian blue staining and immunohistochemistry(IHC). 1.2 h after injection of SPION MBs, T2* of the liver had decreased to its minimum. Theelimination half-life of SPION MBs was 598 : 2 ? 97 : 3 h, while the half-life for SPION was222 : 6 ? 26 : 4 h. Moreover, our study showed that SPION MBs were taken up by the macrophagesin the lungs, spleen and liver. MBs labeled with SPION can be used for MR imaging. Moreover,MRI is a reliable and noninvasive tool that can be utilized in pharmacokinetic investigations offuture contrast agents using SPION MBs and SPION in the rat.
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