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( Hector Raul Ibarra Sifuentes ),( Carlos Javier Rodriguez Alvarez ),( Erick Joel Rendon Ramirez ),( Perla Rocio Colunga Pedraza ),( Iris Jazmin Colunga Pedraza ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The Glasgow-Blatchford scale has been used to classify patients into low or high risk and the need for medical or endoscopic treatment Methods: A cross-sectional study, which retrospectively Blatchford scale is calculated for patients with nVUGIB, requiring blood transfusion, to determine the likelihood of blood transfusion, using Pearson correlation applying SPSS Statistics 18; in a period beginning from January 1, 2009 to December 31, 2013 Results: 42 patients with diagnosis of nVUGIB were studied, of which 26 patients (61.9%) required blood transfusion. By sex the highest percentage was 65% for men (17 men and 9 women). 95.3% of the patients had a Blatchford scored greater than 0 and 61.9% required blood transfusion. A Pearson correlation index of 0.815 was found. Conclusions: The Pearson correlation showed a positive relationship between the variables, finding that the Blatchford scale was useful in determining which patients required blood transfusion when a cutoff 3 was used.
Medina-Jaime, Alma Delia,Reyes-Vargas, Francianella,Martinez-Gaytan, Victoria,Zambrano-Galvan, Graciela,Portillo-DelCampo, Eduardo,Burciaga-Nava, Jorge Alberto,Reyes-Romero, Miguel,Sifuentes-Alvarez, Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
The aim of this work was to analyze methylation of the promoter sites of the ESR1 and PGR genes and to determine correlations with immunohistochemical expression of estrogen and progesterone receptors in ductal and lobular breast cancers. An observational, descriptive, molecular study was conducted on 20 ductal and 20 lobular breast cancer samples with immunohistochemical determination of estrogen and progesterone receptor expression. The methylation analysis of ESR1 and PGR promoter sites was carried-out by methylation-specific PCR. For correlation analysis, Kendall's tau coefficient was determined. Positive correlations were found between estrogen and progesterone receptors, estrogen receptor and unmethylated progesterone receptor, progesterone receptor, and unmethylated progesterone receptor. Negative correlations were found between estrogen receptor and methylated progesterone receptor, progesterone receptor and methylated progesterone receptor, methylated and unmethylated estrogen receptor, and methylated and unmethylated progesterone receptor. The results suggest that methylation of promoter sites of ESR1 and PGR is a relatively uncommon event in ductal and lobular breast cancer, and also suggest that the determination of epigenetic states of ESR1 and PGR could represent an alternative or complement to the histopathological expression analysis.