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Kentaro Atsukawa,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.101 No.-
From the designs of product and industrial process perspectives, the solubility of a target material is oneof the most valuable qualities. We proposed the ‘solid dispersion melt crystallization (SDMC) concept’ asa original strategy for dispersing a target material in a matrix one, in which the target material is naturallydispersed between the crevices formed by the matrix material precipitatedfirst. Furthermore, the effectsof introducing some operations, such as cooling, agitation and aeration, to the SDMC concept on thedissolution rate were investigated by a binary eutectic system. According to the experimental results, thedissolution rate was enhanced by the operations (cooling, agitation and aeration). This improvement inthe dissolution rate was attributed to the SDMC concept-based enhancement of the nucleation rate. Therefore, it was revealed that an increase in the nucleation rate due to the SDMC concept had effectivelyimproved the dissolution rate.
Kentaro Atsukawa,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.106 No.-
Quality control of the crystalline materials obtained from melts with the difficulty of nucleation is challenging. When nucleation is enhanced in such melts, the quality distribution is improved. Herein, the aerationmethod, which enhances nucleation in solution systems, was employed in a melt to investigate theaeration effect on nucleation in a melt and the effect of the crystallization conditions with aeration on theinduction time sind. Experimental results show that aeration enabled nucleation in a melt under supercoolingconditions, where nucleation could not occur without aeration. Furthermore, sind depended onthe operating conditions with aeration (initial supercooling, aeration period, and atmospheric temperature). The crystal size in the obtained solid phase decreased as the atmospheric temperature decreased. These results suggest that the desired nucleation timing and crystal size can be obtained by manipulatingthe crystallizer and aeration conditions. Thus, aeration is promising for improving the quality distributionsin crystalline materials.
Development of novel cascade type crystallizer for continuous production of crystalline particles
Mana Koyama,Shoji Kudo,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-
The introduction of a continuous crystallization process has been attracting attention for thepharmaceutical products. We designed a novel continuous crystallizer, which includes Couette–Taylorequipment integrated with MSMPR equipment in a cascading manner. Additionally, feed solutions weresupplied to MSMPR and Couette–Taylor equipment toflexibly control the supersaturation of the MSMPRequipment, regardless of the supersaturation of Couette–Taylor equipment. In this study, the relationshipbetween operating parameters in novel cascade–type crystallizer andfinal crystal quality wasinvestigated. We found that the quality of the obtained crystalline particles depend on theflow-rate ratioof the feed solution supplied to Couette–Taylor equipment. Furthermore, the yield of crystalline productswas improved using proposed crystallizer. Therefore, we expect proposed novel cascade–typecrystallizer consisting of Couette–Taylor and MSMPR equipment to obtain crystalline products withvarious quality.
Mitsuki Ohyama,Shoji Kudo,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.75 No.-
The quality of crystalline particles is determined by many kinds of characteristics. Therefore, it isnecessary to evaluate each characteristic comprehensively. In this study, the uniformity of eachcharacteristic of the crystalline particles was defined and proposed as performance index “homogeneity”,and the operation method of reaction crystallization for improvement the crystal qualities wasdeveloped. Homogeneity was evaluated by using the uniformity of particle size and crystal shape. Furthermore, in order to produce the crystalline particles with high homogeneity, it was necessary toconsider the effects of solution pH and the mixing methods of two solutions.