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Shuhei Fujita,Makoto Tomita,문승호,Hirokuni Arai 한국자료분석학회 2013 Journal of the Korean Data Analysis Society Vol.15 No.3
In clinical practice, medical professionals are likely to rely on various scoring systems and their suggested cutoffs to evaluate the severity of disease or the risk to patients and the key of scoring system and database is the reliable cutoff. We herein report a novel and concise method to calculate the significant cutoff by exploiting serial testing with the result of tricuspid valve surgery. In tricuspid surgery, tricuspid annuloplication with annuloplasty ring has been common procedure to fix tricuspid regurgitation, but the optimal ring size has not been determined. We defined the new index TARI (Tricuspid Annuloplasty Ring size Index), which normalizes the ring size by body surface area. We tested all cutoff candidates of TARI sequentially and confirmed which value was the most significant cutoff to achieve the best result. Our method would be simple and be widely applicable for any dataset that has negative or positive correlations.
Tsumura, Hideyasu,Matsumoto, Kazumasa,Ikeda, Masaomi,Yanagita, Kengo,Hirano, Shuhei,Hagiwara, Masahiro,Nagashio, Ryo,Fujita, Tetsuo,Sato, Yuichi,Iwamura, Masatsugu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Background: Uroplakins have been widely investigated as potential markers in patients with bladder cancer because these proteins are specific to the urothelium. However, the role of uroplakin proteins in bladder cancer remains unknown. In this study, preoperative serum levels of uroplakin III were measured in patients with urothelial carcinoma of the urinary bladder and examined for possible association with clinicopathological features and clinical outcomes. Materials and Methods: This study included 52 bladder cancer patients at various stages and 28 healthy controls. Uroplakin III levels were detected in preoperative sera using an automated dot blot system and a micro-dot blot array. Results: There was a significant increase in serum uroplakin III levels in patients with bladder cancer as compared to healthy controls (p<0.05). In addition, serum uroplakin III levels were associated with muscle-invasive status, high grade and lymphovascular invasion (p<0.02). Log-rank tests indicated high serum uroplakin III to be significantly associated with cancer-specific mortality. Conclusions: Determination of serum uroplakin III level could be valuable for identifying patients with biologically aggressive bladder cancer.