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Momoko Nishimaru,Shoji Kudo,Hiroshi Takiyama 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.36 No.-
The cocrystallization operation has the deposition risk of undesired crystals. In this study, the strategy ofcocrystal production method considering the risk reduction of undesired single component crystaldeposition was investigated. The anti-solvent cocrystallization was carried out in four-componentsystem of carbamazepine (CBZ), saccharin (SAC), methanol and water. The undesired single componentcrystals precipitated depending on the solution addition sequences. Considering the driving force foreach component, a domain without the deposition risk of the undesired crystals was determined on thephase diagram. It is important to keep the operation point in this domain for production of desiredcocrystals.
Mitsuki Ohyama,Shoji Kudo,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.75 No.-
The quality of crystalline particles is determined by many kinds of characteristics. Therefore, it isnecessary to evaluate each characteristic comprehensively. In this study, the uniformity of eachcharacteristic of the crystalline particles was defined and proposed as performance index “homogeneity”,and the operation method of reaction crystallization for improvement the crystal qualities wasdeveloped. Homogeneity was evaluated by using the uniformity of particle size and crystal shape. Furthermore, in order to produce the crystalline particles with high homogeneity, it was necessary toconsider the effects of solution pH and the mixing methods of two solutions.
Development of novel cascade type crystallizer for continuous production of crystalline particles
Mana Koyama,Shoji Kudo,Shuntaro Amari,Hiroshi Takiyama 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-
The introduction of a continuous crystallization process has been attracting attention for thepharmaceutical products. We designed a novel continuous crystallizer, which includes Couette–Taylorequipment integrated with MSMPR equipment in a cascading manner. Additionally, feed solutions weresupplied to MSMPR and Couette–Taylor equipment toflexibly control the supersaturation of the MSMPRequipment, regardless of the supersaturation of Couette–Taylor equipment. In this study, the relationshipbetween operating parameters in novel cascade–type crystallizer andfinal crystal quality wasinvestigated. We found that the quality of the obtained crystalline particles depend on theflow-rate ratioof the feed solution supplied to Couette–Taylor equipment. Furthermore, the yield of crystalline productswas improved using proposed crystallizer. Therefore, we expect proposed novel cascade–typecrystallizer consisting of Couette–Taylor and MSMPR equipment to obtain crystalline products withvarious quality.