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      • Validation of trip-induction system on a treadmill by comparison with a walking lane

        Hazuki Miyata,Akiyama Yasuhiro,Yoji Yamada,Shogo Okamoto 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10

        Trip-related falls, which account for a significant portion of falls by the elderly, often result in serious injury. A method to evaluate fall risk accurately will be increasingly required in the aging society. For this purpose, it is necessary to analyze the natural reaction motion against tripping. We therefore developed a device and method to induce tripping at an arbitrary time during walking on a treadmill. To evaluate the validity of that method, another experiment that induced tripping on a walking lane was conducted. The reaction motions in the two environments were then compared. In this study, we focused on the difference in the preferred walking speed between the ground and the treadmill. The results suggest that the joint patterns during the reaction motion become similar when the subjective velocities, not the physical velocities, become the same for the subject, whereas physical parameters such as the trajectory of the center of mass become similar when the physical velocities match. These results help to understand the reaction motion against tripping and to reproduce the natural reaction motion on the treadmill.

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        Metallic Vessel with Mesh Culture Surface Fabricated Using Three-dimensional Printing Engineers Tissue Culture Environment

        Chikahiro Imashiro,Takashi Morikura,Motoaki Hayama,Atsushi Ezura,Jun Komotori,Shogo Miyata,Sakaguchi Katsuhisa,Shimizu Tatsuya 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.1

        Various culture devices have been developed as fundamental technologies for facilitating bioengineering studies. Culture devices are designed to prepare specific culture environments. Thus, both macrostructures and surface micromorphology should be considered in the device design. Although fabricating devices with elaborate designs incurs high production costs, disposable materials are typically used for culture devices. However, some metallic materials are strong, stable, and biocompatible. Bioengineers have not applied these materials to culture devices because of the difficulty of processing. An emerging technology using three-dimensional (3D) printing has been developed, which can produce complex designs using metal. We demonstrate the applicability and potential of metal 3D printing for fabricating culture devices toward the development of the bioengineering discipline. As a specific example, we fabricated metallic culture devices where the environment of cultured tissues can be improved. One of the biggest factors determining the culture environment is active media supply. To attain active media supply to the tissue, devices having culture surfaces with mesh structures having holes far larger than cells were proposed. Cell sheets were cultured as tissue models, realizing tissue culture with such structures. The cultured tissue showed increased metabolism, indicating enhanced media supply owing to mesh surfaces. The biocompatibility of the 3D printed metal device was confirmed by viability assays on cultured cells, and reusability of the device was confirmed by mechanical and biochemical evaluations. We believe this study serves as a reference for using metallic 3D printing as an option for fabricating culture devices, which will promote bioengineering research.

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