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- 저자 : Shiqiang Feng (검색결과 2 건)
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Yong Yang,Ning Hao,Yicong Xue,Shiqiang Feng,Yunlong Yu,Shuchen Zhang 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.84 No.3
In this paper, the impact on seismic performance of an economical effective technique for retrofitting reinforced concrete (RC) columns using high-strength steel strips under high axial compression ratios was presented. The experimental program included a series of cyclic loading tests on one nonretrofitted control specimen and three retrofitted specimens. The effects of the axial compression ratio and spacing of the steel strips on the cyclic behavior of the specimens were studied. Based on the test results, the failure modes, hysteretic characteristics, strength and stiffness degradation, displacement ductility, and energy dissipation capacity of the specimens were analyzed in-depth. The analysis showed that the transverse confinement provided by the high-strength steel strips could effectively delay and restrain diagonal crack development and improve the failure mode, which was flexural-shear failure controlled by flexural failure with better ductility. The specimens retrofitted using high-strength steel strips showed more satisfactory seismic performance than the control specimen. The seismic performance and deformation capacity of the retrofitted RC columns increased with decreasing axial compression ratio and steel strip spacing. Based on the test results, a hysteretic model for RC columns that considers the transverse confinement of high-strength steel strips was then established. The hysteretic model showed good agreement with the experimental results, which verified the effectiveness of the proposed hysteretic model. Therefore, the aforementioned analysis can be used for the design of retrofitted RC columns.
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Imaging Cell Surface Glycans ofCardiomyocytes in Intact Rat Heart
Jie Rong,Jing Han,Lianshun Feng,Yanhong Tan,Qiwei Wang,Yingying Chen,Shiqiang Wang,Xing Chen 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Glycosylation is essential for proper cell signaling and embryonic development. Changes in glycosylation are often a hallmark of disease states. Cardiovascular disease has become one of the top causes of death. Many studies using rat models have related heart diseases and regulations of heart physiological functions to altered glycosylations. However, the dynamic regulation and molecular mechanism of glycosylation in heart are not clear. Rat is an important model organism for human cardiovascular disease studies. Isolated intact rat hearts are often used in physiological and pathological studies. In situ imaging biomolecules in intact heart avoid possible damage of myocyte and biased loss of cardiac myocytes during enzymatic isolation. Here, we applied the metabolic glycan labeling technique for imaging sialylation and O-linked glycosylation in living cardiomyocytes and intact rat hearts. The effects of unnatural sugars on the function of cardiomyocytes and hearts were evaluated. We found unnatural sugars did not perturb the function of cardiomyocytes and hearts. Glycan imaging revealed an interesting distribution pattern: sialic acid or O- linked glycan enriched at intercalated discs of adult rat cardiomyocytes. We also observed that the glycosylations of cardiomyocytes were altered in isoproterenol-induced cardiac hypertrophy rat models. This work extends the application of metabolic glycan labeling technique to probe glycosylations in rats and provides the first example of using this technique for in situ cellular glycans imaging in mammalian model organisms. The biological significance of altered glycosylations in cardiac hypertrophy heart is under investigation in our lab.
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