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      • The Lexicon Project: Identifying and Unpacking the Technical Vocabulary of Japanese Mathematics Teachers

        ( Shimizu ),( Yoshinori ) 한국수학교육학회 2017 수학교육 학술지 Vol.2017 No.2

        The Japanese tradition of Lesson Study has created a teaching community in which observation and discussion of teaching are integral parts of professional practice with particular lexical terms of specific significance. The current study aims to address the terms that Japanese teachers use to describe the phenomena of the school mathematics classroom. The study explores the constituent elements and structural characteristics of the Japanese lexicon, as a part of the international Lexicon Project that aims to document and compare the naming systems in nine participating countries. Each participating team contributed a videotaped lesson to be included in a stimulus package viewed by team members in each country to identify the wellestablished pedagogical terms or phrases of used in the communities. We created a lexicon of 76 terms and their extensive descriptions. An electronic survey was conducted for a national validation to examine how familiar the terms were for the mathematics teachers in Japan. Overall, the terms were very familiar to the respondents, although some terms were somewhat less frequently in use. An evolving nature of lexical terms has appeared through the process of analyses. Issues and challenges in studying local Lexicon are discussed.

      • SCOPUSKCI등재

        Long-Term Durability of Infliximab for Pediatric Ulcerative Colitis: A Retrospective Data Review in a Tertiary Children's Hospital in Japan

        Shimizu, Hirotaka,Arai, Katsuhiro,Takeuchi, Ichiro,Minowa, Kei,Hosoi, Kenji,Sato, Masamichi,Oka, Itsuhiro,Kaburaki, Yoichiro,Shimizu, Toshiaki The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.1

        Purpose: The long-term efficacy and safety of infliximab (IFX) in children with ulcerative colitis (UC) have not been well-evaluated. Here, we reviewed the long-term durability and safety of IFX in our single center pediatric cohort with UC. Methods: This retrospective study included 20 children with UC who were administered IFX. Results: For induction, 5 mg/kg IFX was administered at weeks 0, 2, and 6, followed by every 8 weeks for maintenance. The dose and interval of IFX were adjusted depending on clinical decisions. Corticosteroid (CS)-free remission without dose escalation (DE) occurred in 30% and 25% of patients at weeks 30 and 54, respectively. Patients who achieved CS-free remission without DE at week 30 sustained long-term IFX treatment without colectomy. However, one-third of the patients discontinued IFX treatment because of a primary nonresponse, and one-third experienced secondary loss of response (sLOR). IFX durability was higher in patients administered IFX plus azathioprine for >6 months. Four of five patients with very early onset UC had a primary nonresponse. Infusion reactions (IRs) occurred in 10 patients, resulting in discontinuation of IFX in four of these patients. No severe opportunistic infections occurred, except in one patient who developed acute focal bacterial nephritis. Three patients developed psoriasis-like lesions. Conclusion: IFX is relatively safe and effective for children with UC. Clinical remission at week 30 was associated with long-term durability of colectomy-free IFX treatment. However, approximately two-thirds of the patients were unable to continue IFX therapy because of primary nonresponse, sLOR, IRs, and other side effects.

      • KCI등재후보

        Study of the Oral Discomfort and Oral Habits in Halitosis Patient

        Toshiyuki Shimizu,Mie Tashiro,Michael W. Myers,Kohji Takahashi,Shun-Ichi Honda 대한예방치과학회 2012 International Journal of Clinical Preventive Denti Vol.8 No.1

        Objective: Purpose of this study was to clarify the relationship between oral discomfort, oral habits and halitosis. Methods: One hundred and forty patients with halitosis (age range, 13 to 65 years; 93 women, 47 men) who had visited Shimizu dental clinic from October 2003 to August 2008 were compared with a control group who did not have complaints about halitosis (n=56). Oral discomfort (such as sensation of dry mouth and discomfort of the tongue), the amount of saliva secretion, and oral habits (such as bruxism) were analyzed statistically between the halitosis and control group. To compare the halitosis patients with the control group, the Wilcoxon signed-ranks test was used for the analysis of the salivary amount, and a chi-Square test was used for the analysis of oral discomfort and oral habits. Results: Frequency of oral discomfort mouth sensation was significantly higher (p<0.0001) in the halitosis patients (63.5%) than in the control group (10.7%). The occurrence of oral habit was significantly higher (p<0.001) in the halitosis patients (63.6%) than in the control group (37.5%). There was a significant difference (p=0.0009) between the halitosis patients (mean: 1.28 ml) and control group (mean: 1.43 ml) in the amount of unstimulated saliva secretion. For the amount of stimulated saliva secretion, there was no significant difference (p=0.2248) between the halitosis patients (mean: 3.40 ml) and control group (mean: 3.76 ml). Conclusion: These results suggest that the presence of oral discomfort and oral habits, such as bruxism, were associated with halitosis.

      • SCOPUSKCI등재

        Recent Advances in the Development of PET/SPECT Probes for Atherosclerosis Imaging

        Shimizu, Yoichi,Kuge, Yuji The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.4

        The rupture of vulnerable atherosclerotic plaques and subsequent thrombus formation are the major causes of myocardial and cerebral infarction. Accordingly, the detection of vulnerable plaques is important for risk stratification and to provide appropriate treatment. Inflammation imaging using 2-deoxy-2-[$^{18}F$]fluoro-D-glucose ($^{18}F-FDG$) has been most extensively studied for detecting vulnerable atherosclerotic plaques. It is of great importance to develop PET/SPECT probes capable of specifically visualizing the biological molecules involved in atherosclerotic plaque formation and/or progression. In this article, we review recent advances in the development of PET/SPECT probes for visualizing atherosclerotic plaques and their application to therapy monitoring, mainly focusing on experimental studies.

      • Monitoring of tool wear for high precision blanking using AE technique

        SHIMIZU, Tomoharu,NISHI, Junichiro,IWABUCHI, Akira ENGINEERING TRIBOLOGY RESEARCH INSTITUTE KYUNGPOOK 1999 INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE OF TRI Vol.1999 No.-

        It is important to estimate progress of the tool wear of press working, because the tool wear cause low precision products. So, the aim of this research is establishment in a monitoring technique of press tool wear. Acoustic emission (AE) were measured during high precision blanking. An auto-regressive (AR) model analysis were conducted for the AE signals. Then, AR parameters obtained were analyzed with principal component analysis, which is one of multivarate analysis method. The correlations between the change in AR parameters and the degree of the progress of the tool wear were examined. The possibility of monitoring of the tool wear for the press working was indicated.

      • SCIESCOPUSKCI등재

        Functional Analyses and Application of Microbial Lactonohydrolases

        Shimizu, Sakayu,Honda, Kohsuke,Kataoka, Michihiko The Korean Society for Biotechnology and Bioengine 2002 Biotechnology and Bioprocess Engineering Vol.7 No.3

        Microbial lactonohydrolases (intramolecular ester bond-hydrolyzing enzymes) with unique properties were found. The lactonohydrolase from Fusarium oxysporum catalyzes enantiose-lective hydrolysis of aldonate lactones and D-pantoyl lactone (D-PL). This enzyme is useful for the large-scale optical resolution of racemic PL. The Agrobacterium tumefaciens enzyme catalyzes asymmetric hydrolysis of PL, but the stereospecificity is opposite to that of the Fusarium enzyme. Dihydrocoumarin hydrolase (DHase) from Acinetobacter calcoaceticus is a bifunctional enzyme, which catalyzes not only hydrolysis of aromatic lactones but also bromination of monochlorodi-medon in the presence of H$_2$O$_2$and dihydrocoumarin. DHase also hydrolyzes several linear esters, and is useful for enantioselective hydrolysis of methyl DL-$\beta$-acetylthioisobutyrate and regioselective hydrolysis of methyl cetraxate.

      • Two-Dimensional Superstructure Formation of Fluorinated Fullerene on Au(111): A Scanning Tunneling Microscopy Study

        Shimizu, Tomoko K.,Jung, Jaehoon,Otani, Tetsuya,Han, Young-Kyu,Kawai, Maki,Kim, Yousoo American Chemical Society 2012 ACS NANO Vol.6 No.3

        <P>A two-dimensional fluorinated fullerene (C<SUB>60</SUB>F<SUB>36</SUB>) superstructure has been successfully formed on Au(111) and was investigated using scanning tunneling microscopy (STM) and density functional theory calculations. Although there exist three isomers (<I>C</I><SUB>3</SUB>, <I>C</I><SUB>1</SUB>, and <I>T</I>) in our molecular source, STM images of the molecules in the well-ordered region all appear identical, with 3-fold symmetry. This observation together with the differences in the calculated lowest unoccupied molecular orbital (LUMO) distribution among the three isomers suggests that a well-ordered monolayer consists of only the <I>C</I><SUB>3</SUB> isomer. Because of the strong electron-accepting ability of C<SUB>60</SUB>F<SUB>36</SUB>, the adsorption orientation can be explained by localized distribution of its LUMO, where partial electron transfer from Au(111) occurs. Intermolecular C–F···π electrostatic interactions are the other important factor in the formation of the superstructure, which determines the lateral orientation of C<SUB>60</SUB>F<SUB>36</SUB> molecules on Au(111). On the basis of scanning tunneling spectra obtained inside the superstructure, we found that the LUMO is located at 1.0 eV above the Fermi level (<I>E</I><SUB>F</SUB>), while the highest occupied molecular orbital (HOMO) is at 4.6 eV below the <I>E</I><SUB>F</SUB>. This large energy gap with the very deep HOMO as well as uniform electronic structure in the molecular layer implies a potential for application of C<SUB>60</SUB>F<SUB>36</SUB> to an electron transport layer in organic electronic devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2012/ancac3.2012.6.issue-3/nn300064x/production/images/medium/nn-2012-00064x_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn300064x'>ACS Electronic Supporting Info</A></P>

      • Simulation of Stick-slip Motion of Serial Printer Caused Surface Roughness

        SHIMIZU, Tomoharu,IWABUCHI, Akira,UCHIDATE, Michimasa,KATANO, Keiji ENGINEERING TRIBOLOGY RESEARCH INSTITUTE KYUNGPOOK 2000 INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE OF TRI Vol.2000 No.-

        A serial printer sometimes generates a vertical striped pattern in the printing image. This is known as jitter and can be considered to be caused by vibration of the print-head carriage system. The vibration of carriage is due to a lot of factors, step driving of the stepping motor, meshing between the belt and the pulley, meshing of the reduction gears, and friction between the linear sliding bearing and the sliding shaft. In this paper, the motion of the carriage is examined concerned with the influence of the carriage is examined concerned with the influence of the friction. Frictional models based on roughness theory, adhesion theory and combined both are considered. 3-D surface data generated numerically are used for calculation of friction. Simulations of carriage motion are carried out with a numerical integration method. In this simulation, N.G.(no good) shaft and normal shaft are examined for the carriage motion. It is shown that the influence of the surface waviness of sliding shaft is larger than the surface roughness.

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