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RISS 인기검색어
- 검색키워드
- 저자 : Shi-Kang Shen (검색결과 4 건)
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Joshi, Trinity,Kang, Ji-Hun,Jiang, Lili,Wang, Sheng,Tarigo, Theron,Lyu, Tairu,Kahn, Salman,Shi, Zhiwen,Shen, Yuen-Ron,Crommie, Michael F.,Wang, Feng American Chemical Society 2017 Nano letters Vol.17 No.6
<P>Surface plasmons (SPs) and phonon polaritons (PhPs) are two distinctive quasiparticles resulting from the strong coupling of photons with electrons and optical phonons, respectively. In this Letter, we investigate the interactions between one-dimensional (1D) plasmons in silver nanowires with two-dimensional (2D) surface phonon polaritons of the silicon carbide (SiC) substrate. Using near-field infrared spectroscopy of the silver nanowire–SiC heterostructure at wavelengths close to the phonon resonance of SiC, we observe that the 1D plasmon dispersion is strongly modified by the 2D phonon polaritons in SiC. In particular, we observe for the first time well-defined 1D plasmon oscillations with the plasmon wavelengths longer than the free-space photon wavelengths due to the 1D plasmon–2D phonon polariton coupling. Our work demonstrates that unusual polariton behavior can emerge from interactions between polariton excitons of different dimensionality, which can enable new ways to engineer plasmons in hybrid structures.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2017/nalefd.2017.17.issue-6/acs.nanolett.7b00845/production/images/medium/nl-2017-00845x_0005.gif'></P>
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Phase II study of sunitinib as second-line treatment for advanced gastric cancer
Bang, Yung-Jue,Kang, Yoon-Koo,Kang, Won K.,Boku, Narikazu,Chung, Hyun C.,Chen, Jen-Shi,Doi, Toshihiko,Sun, Yan,Shen, Lin,Qin, Shukui,Ng, Wai-Tong,Tursi, Jennifer M.,Lechuga, Maria J.,Lu, Dongrui Ray,R Springer US 2011 Investigational new drugs Vol.29 No.6
<P><B>Summary</B></P><P><I>Purpose.</I> This phase II, open-label, multicenter study assessed the oral, multitargeted, tyrosine kinase inhibitor sunitinib in patients with advanced gastric or gastroesophageal junction adenocarcinoma who had received prior chemotherapy. <I>Experimental design</I>. Patients received sunitinib 50 mg/day on Schedule 4/2 (4 weeks on treatment, followed by 2 weeks off treatment). The primary endpoint was objective response rate; secondary endpoints included clinical benefit rate, duration of response, progression-free survival (PFS), overall survival (OS), pharmacokinetics, pharmacodynamics, safety and tolerability, and quality of life. <I>Results</I>. Of 78 patients enrolled, most had gastric adenocarcinoma (93.6%) and metastatic disease (93.6%). All were evaluable for safety and efficacy. Two patients (2.6%) had partial responses and 25 patients (32.1%) had a best response of stable disease for ≥6 weeks. Median PFS was 2.3 months (95% confidence interval [CI], 1.6–2.6 months) and median OS was 6.8 months (95% CI, 4.4–9.6 months). Grade ≥3 thrombocytopenia and neutropenia were reported in 34.6% and 29.4% of patients, respectively, and the most common non-hematologic adverse events were fatigue, anorexia, nausea, diarrhea, and stomatitis. Pharmacokinetics of sunitinib and its active metabolite were consistent with previous reports. There were no marked associations between baseline soluble protein levels, or changes from baseline, and measures of clinical outcome. <I>Conclusions</I>. The progression-delaying effect and manageable toxicity observed with sunitinib in this study suggest that although single-agent sunitinib has insufficient clinical value as second-line treatment for advanced gastric cancer, its role in combination with chemotherapy merits further study.</P>
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Wang, Yan,Zhang, Pei,An, Le,Ma, Guangkai,Kang, Jiayin,Shi, Feng,Wu, Xi,Zhou, Jiliu,Lalush, David S,Lin, Weili,Shen, Dinggang IOP 2016 Physics in medicine & biology Vol.61 No.2
<P>Positron emission tomography (PET) has been widely used in clinical diagnosis for diseases and disorders. To obtain high-quality PET images requires a standard-dose radionuclide (tracer) injection into the human body, which inevitably increases risk of radiation exposure. One possible solution to this problem is to predict the standard-dose PET image from its low-dose counterpart and its corresponding multimodal magnetic resonance (MR) images. Inspired by the success of patch-based sparse representation (SR) in super-resolution image reconstruction, we propose a mapping-based SR (<I>m</I>-SR) framework for standard-dose PET image prediction. Compared with the conventional patch-based SR, our method uses a mapping strategy to ensure that the sparse coefficients, estimated from the multimodal MR images and low-dose PET image, can be applied directly to the prediction of standard-dose PET image. As the mapping between multimodal MR images (or low-dose PET image) and standard-dose PET images can be particularly complex, one step of mapping is often insufficient. To this end, an incremental refinement framework is therefore proposed. Specifically, the <I>predicted</I> standard-dose PET image is further mapped to the <I>target</I> standard-dose PET image, and then the SR is performed again to predict a new standard-dose PET image. This procedure can be repeated for prediction refinement of the iterations. Also, a patch selection based dictionary construction method is further used to speed up the prediction process. The proposed method is validated on a human brain dataset. The experimental results show that our method can outperform benchmark methods in both qualitative and quantitative measures.</P>
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Chlorophyll Fluorescence Characteristics and Rapid Light Response Curves of Alpine Rhododendron
Yuan-Huan Liu,Fang-Li Liu,Bo Long,Xiong-Li Zhou,Xue Zhang,Yue Zhang,Wen-Li Wang,Shi-Kang Shen 한국원예학회 2019 원예과학기술지 Vol.37 No.4
The aim of this study was to determine the photosynthetic adaptability of Rhododendron species toalpine environments. The chlorophyll fluorescence parameters and rapid light response curves ofeight Rhododendron species were determined under field conditions across elevation gradients (atelevations of 2,950, 3,560, 3,660, 3,770, and 4,030 m) in the Jiaozi Mountain National NaturalReserve, Yunnan Province, southwestern China. The effect of different elevations, species, and theirinteractions significantly affected most of the chlorophyll fluorescence and rapid light response curveparameters. The variable to maximum fluorescence ratio (Fv/Fm) ranged from 0.78 to 0.81 at the fiveelevation gradients. This result indicated that the studied species were well grown and adapted to thecurrent environment. The correlation analysis indicated that the elevation was positively significantlycorrelated with the photochemical efficiency of photosystem II, electron transport rate, maximumelectron transport rate, light saturation coefficient (Ek), and chlorophyll relative content (SPAD: leafchlorophyll content index) and was negatively significantly correlated with photochemicalquenching, nonphotochemical quenching, and linear initial slope values. Although no significantrelationship was observed between the elevations and Fv/Fm, the apparent difference in Fv/Fm both atelevation gradients and elevation × species levels indicated that the Rhododendron speciesdemonstrated species-specific adaptation to the environment at different elevations. Our resultsprovided evidence that Rhododendron species exhibit variations in photosynthetic activities in analpine environment at different elevations. These differences may improve the understanding of thephysiological adaptation variations of Rhododendron species across elevation gradients in associationwith climate change in the mountains of southwestern China.
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