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Two new quinones from the roots of Juglans mandshurica
Mei Jin,Jinfeng Sun,Ren Li,Shengbao Diao,Changhao Zhang,Jiong-Mo Cui,손종근,Wei Zhou,Gao Li 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.9
Two new quinones, 1-hydroxy-5-pentyl-anthraquinone (1) and 4-(5-hydroxy-1,4-dioxo-1,4-dihydronaphthalen- 2-ylamino)-butyric acid methyl ester (2), together with two known quinones, 5-hydroxy-2-(2-hydroxy- ethylamino)-(1,4) naphthoquinone (3) and juglone (4) were isolated from the roots of Juglans mandshurica (Juglandaceae). Their structures were elucidated on the basis of spectral data. Compound 3 was isolated from the Juglans genus for the first time. Compounds 1–4 exhibited significant cytotoxicity towards cultured MDA-MB231, HepG2 and SNU638 cells with IC50 values ranging from 4.46 to 88.47 μM.