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- 저자 : Seulki Roh (검색결과 35 건)
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A case of malignant fibrous histiocytoma on the upper arm
( Seulki Lee ),( Shinyoung Song ),( Seha Park ),( Jeongsoo Kim ),( Heejoo Kim ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Malignant fibrous histiocytoma (MFH) is a soft tissue sarcoma that most commonly occurs on the extremities in middle and late adulthood. It has recently been classified as undifferentiated pleomorphic sarcoma (UPS). It has often been confused with other sarcomas because of the highly variable morphologic pattern. Also this tumor has an aggressive biological behavior and a poor prognosis. A 78-year old female presents with 2.0 X 1.0 cm sized tendor, firm, erythematous nodule on left upper arm. That nodule was excised by a primary care dermatologist. Initial pathologic diagnosis was atypical fibroxanthoma. But the tumor recurred locally and grew rapidly (7.0 X 5.0 cm sized) in three months. MFH was suspected and wide excision was performed with negative resection margins. Histopathologic features included pleomorphic cellular morphologies and frequent mitotic figures consistent with MFH. In immunohistochemical staining, the tumor cells were positive with vimentin, CD68 and CD10. It was negative with CD99, S-100 and desmin. The tumor was diagnosed as MFH and there has been no evidence of local recurrence for 6 months. Although the prognosis of recurred MFH is known to be poor, a clear resection could provide better control of the tumor with a lower recurrence risk. Therefore, we suggest a complete wide excision with negative margin is essential for an effective management of MFH.
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( Seulki Lee ),( Shinyoung Song ),( Seha Park ),( Jeongsoo Kim ),( Heejoo Kim ),( Jinok Baek ),( Hyangjoon Park ),( Jooyoung Roh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
More than fifty percent of the chronic spontaneous urticaria (CSU) patients are resistant to standard dose of H1-antihistamine treatment. Omalizumab is an anti-IgE antibody that has proved to be effective in treatment of patients with chronic urticaria refractory to antihistamines. We treated the CSU patients with omalizumab who respond to treatment with high dose antihistamnine. Nineteen patients (male : female=11 : 8 ; mean age,52.4 years) were treated with 150mg or 300mg omalizumab every 4 weeks more than 12 weeks. The duration of CSU before starting omalizumab ranged between 3 months and 12 years (mean, 4.1 years). Mean serum IgE level was 123.3 IU/ml (range 2-278). Treatment efficacy were assessed primarily based on changes from baseline to week 12 in weekly urticaria activity scores (UAS7) and investigator’s global assessment (IGA). After 12 weeks of therapy, the response was evaluated as follows. Mean UAS7 score decreased from 25.8 at baseline to 3.8 after the 12 weeks and mean IGA score decreased from 3.3 to 0.8 after the 12 weeks. Complete remission (UAS7 =0) was seen in 38% of patients who started with 300mg and in 27% of those who started with 150mg. Partial response (UAS7≤6) was observed in 50% of patients. One patient (5%) had no response to omalizumab treatment. This real world experience demonstrated that omalizumab is a well-tolerated, beneficial option for the treatment of CSU patients refractory to antihistamine.
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A case of pediatric hidradenitis suppurativa in girl
( Haryeong Ryu ),( Seulki Lee ),( Jeongsoo Kim ),( Chulhyun Yun ),( Jooyoung Roh ),( Jinok Baek ),( Jongrok Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Hidradenitis suppurativa is a chronic, recurrent inflammatory disorder of the hair follicles that affects apocrine gland bearing sites, such as the axillae and inguinal and perianal areas. Hidradenitis suppurativa is uncommon in children, with onset generally occurring well after puberty, typically between 20 and 24 years of age. We present an 8-year-old girl whose lesions commenced at the age of 6 years as painful nodules in the buttock. There was no family history of hidradenitis suppurativa or severe acne. Examination revealed few erythematous papules, nodules, and atrophic scars in the buttock. Axillary lesion was absent. She had not attained menarche and the breasts and pubic hair were Tanner stage 1. No evidence of androgen excess was noted on physical examination. A skin biopsy showed superficial dermal perivascular lymphocytic infiltration and presence of acute inflammation of apocrine glands. After the exclusion of bacterial and mycotic infections, a diagnosis of hidradenitis suppurativa was made based on the characteristic clinical presentation and the skin biopsy result. The patient had previously been treated with oral and topical antibiotics for intermittent periods with no improvement. She was treated oral roxithromycin (2.5 mg/kg/day) which marked improvement was noted after 4 weeks, and 2 months later she was in complete remission. Herein, we report a rare case of hidradenitis suppurativa in pediatric.
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Squamous cell carcinoma in situ successfully treated with ingenol mebutate 0.015%
( Jeongsoo Kim ),( Seulki Lee ),( Haryeong Ryu ),( Chulhyun Yoon ),( Jinok Baek ),( Jongrok Lee ),( Jooyoung Roh ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Cutaneous squamous cell carcinoma(cSCC) is the second most common skin cancer in the US. Many cSCCs are small low-risk cancers and are usually effectively managed using minor surgical procedures. However, alternative treatment options are sometimes required, for example, when a patient refuses a surgical procedure, surgical treatment is contraindicated due to possible morbidity or cosmetic deformity and patient condition is compromised by age or the presence of comorbidities. Topical therapy is usually preferred by these patients. Ingenol mebutate has a dual mechanism of action involving the rapid induction of cellular death and cellular cytotoxicity triggered by neutrophils and antibodies. And it has limited local side effect and is applied easily. A 92-year-old Asian woman presented at our dermatology clinic with an erythematous, rough, oozing, crusted lesion of the scalp. In 2011, she has been diagnosed with actinic keratosis of the scalp but dropped out. At this presentation the lesion had became more severe and was biopsied under the suspicion of SCC. We decided to treat the lesion with ingenol mebutate gel (0.015%) daily, and administered two cycles of 3 consecutive days per month for two months. One month after the second cycle the lesion had almost resolved and this was confirmed by biopsy. We report a rare case of cSCC in situ that was treated by ingenol mebutate that is considered an alternative to surgery.
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Lee, Seokbae,Roh, Seulki,Seo, Yu-Seong,Lee, Myounghoon,Jung, Eilho,Mok Ok, Jong,Jung, Myung-Chul,Kang, Byungkyun,Lee, Kwan-Woo,Sung Kim, Jun,Hwang, Jungseek IOP 2019 Journal of physics, an Institute of Physics journa Vol.31 No.44
<P>We performed an infrared spectroscopic study on a single crystal of Sr<SUB>2</SUB>VO<SUB>3</SUB>FeAs grown by a self-flux method. This layered material system consists of two alternative layers of [SrVO<SUB>3</SUB>]<SUP>−1</SUP> and [SrFeAs]<SUP>+1</SUP>. Since the typical size of single crystalline Sr<SUB>2</SUB>VO<SUB>3</SUB>FeAs samples is 200 <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/0953-8984/31/44/445602/cmab31cdieqn001.gif'/> 200 <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/0953-8984/31/44/445602/cmab31cdieqn002.gif'/> 10 <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/0953-8984/31/44/445602/cmab31cdieqn003.gif'/>m<SUP>3</SUP> an optical study on this material is challenging. We observed an additional interband transition around 1000 cm<SUP>−1</SUP>, which is absent in other doped Ba-122 Fe-pnictides. The origin of this additional transition is not clearly known yet. We also observed a hidden Fermi liquid behavior. Interestingly, we observed a Fano line-shaped phonon which appears near 555 cm<SUP>−1</SUP> below 200 K and shows a strong blue-shift when the temperature is lowered. The amplitude, width, and asymmetric Fano parameter of this phonon show anomalies at 150 K, which are probably related to an electronic phase observed below 155 K recently by an NMR study (Ok <I>et al</I> 2017 <I>Nat. Commun</I>. <B>8</B> 2167). Our finding may help to understand the electronic phase observed previously in the same material.</P>
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( Haryeong Ryu ),( Seulki Lee ),( Jeongsoo Kim ),( Chulhyun Yun ),( Jooyoung Roh ),( Jongrok Lee ),( Jinok Baek ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Pachydermodactyly (PDD) is a rare, distinct form of digital fibromatosis characterized by acquired, asymptomatic swellings on the back and side of the proximal phalanges or proximal interphalangeal joint areas of the fingers. In case of patients with repetitive hand movements, appreciable improvement has been observed after cessation of the traumatic activity. Intralesional triamcinolone injections and localized surgical resection also have resulted in reduction of soft tissue swelling. A 18-year-old male gave a three year history of progressive swelling of fingers affecting predominantly the proximal interphalangeal joints of the index, middle, 4th, 5th fingers of both hands. The swelling was along the lateral aspects of the joints. There was no history of trauma or pain, and he had a full range of movement. Clinical examination was otherwise unremarkable. He also denied repetitive hand-rubbing movements. There was no family history of the disorder. X-ray of the hands showed soft tissue swelling only, no bony abnormality. Histopathologic examination showed epidermal hyperplasia with acanthosis and hyperkeratosis. Collagen fibers in the reticular dermis are thickened and haphazardly arranged, and increased deposits of connective tissue mucin. Misdiagnosis of the periarticular abnormalities as polyarticular juvenile idiopathic arthritis may lead to needless investigations and inappropriate treatment. Herein, we report a rare case of PDD
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Marginal zone B-cell lymphoma associated with MALT lymphoma of parotid gland
( Jeongsoo Kim ),( Seulki Lee ),( Haryeong Ryu ),( Chulhyun Yoon ),( Jinok Baek ),( Jongrok Lee ),( Jooyoung Roh ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Cutaneous Marginal zone B-cell lymphoma (CMZL) is known as extranodal mucosa associated lymphoid tissue (MALT) lymphoma arising at skin accounting for 11% of various extranodal organs. CMZL has indolent behavior and excellent prognosis but recurrence is common. Typically, it manifests as single or multiple, clustered erythematous or violaceous papules, plaques, or nodules. The lesions occur most commonly on the trunk and upper extremities. Histologically, CMZL is composed of polymorphous infiltrate that includes centrocyte-like, monocytoid, and lymphoplasmacytoid lymphocytes and plasma cells. CMZL can be managed with either conservative skin-directed strategies, such as surgical excision and topical steroid, or radiotherapy. A 78-year-old male patient presented with round elevated soft plaque on his back for 2 years. He was diagnosed as MZL of the parotid gland, and underwent surgical excision, radiotherapy and chemotherapy (CHOP) 9 years ago. Histopathologic of the skin showed nodular infiltrate of lymphocytes forming dense, irregulary shaped aggregates in the reticular dermis to subcutaneous tissue. Immunohistochemistry findings revealed positive for CD20, Bcl-2, CD5 and negative for Cyclin D1. There was no evidence of recurrence of previous lymphoma and no sign of metastasis with PET-CT. He was treated with radiotherapy. We report a rare case of CMZL that was formed from patient who had been diagnosed as MZL of the parotid gland.
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( Jeongsoo Kim ),( Seha Park ),( Seulki Lee ),( Haryeong Ryu ),( Jinok Baek ),( Jooyoung Roh ),( Hyangjoon Park ),( Heejoo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Eosinophilic cytokine profile including IL-23/Th17 axis and their immunomodulatory interaction with other immune cells imply their possible involvement in psoriasis pathogenesis. Objectives: This study was to examine the potential role of eosinophils in imiquimod (IMQ)-induced psoriasiform dermatitis using ΔdblGATA mice, an eosinophil lineage-ablated mouse line. Methods: After topical IMQ application, inflammatory cytokine gene expression and Inflammatory cell populations were analyzed by qRT-PCR and flow cytometry, respectively. Results: Psoriatic features like epidermal thickening, erythema, and scale were less prominent in ΔdblGATA mice after IMQ treatment. Inflammatory cytokines important in psoriasis, like IL-1β, IL-6, IL-22, IL-23, and IL-17, and Th1-/neutrophil-related chemokines CCL2 and CXCL12 were also downregulated, and neutrophils were constantly decreased in the skin, LN, and spleen of ΔdblGATA mice compared to WT mice after IMQ treatment. Although IMQ application increased eosinophils in the skin of WT mice, the absolute cell count was much lower than neutrophils, a major player in psoriasis. Conclusion: The small size of eosinophil population and constant reduction of neutrophil in ΔdblGATA mice than WT mice after IMQ treatment suggest that eosinophils would influence psoriasis indirectly via their inflammatory profile and affecting other mediators in psoriasis, such as neutrophils.
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A 3.9 mW 25-Electrode Reconfigured Sensor for Wearable Cardiac Monitoring System
Long Yan,Joonsung Bae,Seulki Lee,Taehwan Roh,Kiseok Song,Hoi-Jun Yoo IEEE 2011 IEEE journal of solid-state circuits Vol.46 No.1
<P>A low power highly sensitive Thoracic Impedance Variance (TIV) and Electrocardiogram (ECG) monitoring SoC is designed and implemented into a poultice-like plaster sensor for wearable cardiac monitoring. 0.1 Ω TIV detection is possible with a sensitivity of 3.17 V/Ω and SNR > 40 dB. This is achieved with the help of a high quality (Q-factor > 30) balanced sinusoidal current source and low noise reconfigurable readout electronics. A cm-range 13.56 MHz fabric inductor coupling is adopted to start/stop the SoC remotely. Moreover, a 5% duty-cycled Body Channel Communication (BCC) is exploited for 0.2 nJ/b 1 Mbps energy efficient external data communication. The proposed SoC occupies 5 mm × 5 mm including pads in a standard 0.18 μm 1P6M CMOS technology. It dissipates a peak power of 3.9 mW when operating in body channel receiver mode, and consumes 2.4 mW when operating in TIV and ECG detection mode. The SoC is integrated on a 15 cm × 15 cm fabric circuit board together with a flexible battery to form a compact wearable sensor. With 25 adhesive screen-printed fabric electrodes, detection of TIV and ECG at 16 different sites of the heart is possible, allowing optimal detection sites to be configured to accommodate different user dependencies.</P>
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