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- 저자 : Seon Yoong Jo (검색결과 2 건)
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윤택준 ( Taek Joon Yoon ),조선영 ( Seon Yoong Jo ) 한국식품영양학회 2010 韓國食品營養學會誌 Vol.23 No.4
This study was conducted to investigate the effects of Acanthopanax senticosus extracts(ASE) on alcohol administered mice. The administration of Acanthopanax senticosus extracts(60㎎/㎏) had beneficial actions toward alcohol degradation in acute alcohol treated mice. In the acute alcohol degradation experiment, serum alcohol concentration were lower 3 and 6 hours after taking ethanol(5g/㎏) in ASE treated mice. The oral administration of ASE showed decreased gastric mucous membrane damage produced in ethanol treated mice. In addition, intraperitoneal(i.p.) administration of ASE showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. ASE also reduced concentrations of nitric oxide(NO), tumor necrosis alpha(TNF)-α and interleukin(IL)-6 in macrophages that were activated by LPS. These results demonstrate that Acanthopanax senticosus extracts possesses the potential to stimulate alcohol degradation and inhibit inflammatory effects in mice.
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Effects of Fermented Ginseng Extracts on Tumor Metastasis in Mice
Dong Zhou Kang,Dan Liu,Seon Yoong Jo,강태봉,Jin Moo Lee,서형주,Ae-jung Kim,윤택준 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.6
This study was demonstrated that the fermentation of gingseng increases its biological activities,by comparing the anti-tumor and immunostimulating activities of fermented gingseng extracts (FginE) with those of non-fermented ginseng (GinE). In the experimental lung metastasis of colon26-M3.1 carcinoma, the intraperitoneal (i.p.) or peroral (p.o.) administration of FginE showed stronger anti-tumor metastatic activities than those of GinE. When stimulating 2 kinds of extract on macrophages,FginE was shown to have a higher production of interleukin (IL)-12 than GinE. In addition, treatment with FginE induced tumoricidal activity of peritoneal macrophages against colon26-M3.1 cells. When Peyer's patch was cocultured with FginE, the proliferation of these cells and granulocyte macrophage-colony stimulating factor (GMCSF)production were induced. In an assay for natural killer (NK) cell activity, an i.p. administration of FginE significantly augmented NK cytotoxicity against Yac-1tumor cells. Fermented ginseng extracts promotes antitumor activities to inhibit tumor metastasis, and its antitumor effects are associated with the enhancement of systemic as well as mucosal immune systems.
ScienceON
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