http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Accelerated Cardiac Diffusion Tensor Imaging Using Joint Low-Rank and Sparsity Constraints
Ma, Sen,Nguyen, Christopher T.,Christodoulou, Anthony G.,Luthringer, Daniel,Kobashigawa, Jon,Lee, Sang-Eun,Chang, Hyuk-Jae,Li, Debiao IEEE 2018 IEEE Transactions on Biomedical Engineering Vol.65 No.10
<P>Objective: The purpose of this paper is to accelerate cardiac diffusion tensor imaging (CDTI) by integrating low-rankness and compressed sensing. Methods: Diffusion-weighted images exhibit both transform sparsity and low-rankness. These properties can jointly be exploited to accelerate CDTI, especially when a phase map is applied to correct for the phase inconsistency across diffusion directions, thereby enhancing low-rankness. The proposed method is evaluated both ex vivo and in vivo, and is compared to methods using either a low-rank or sparsity constraint alone. Results: Compared to using a low-rank or sparsity constraint alone, the proposed method preserves more accurate helix angle features, the transmural continuum across the myocardium wall, and mean diffusivity at higher acceleration, while yielding significantly lower bias and higher intraclass correlation coefficient. Conclusion: Low-rankness and compressed sensing together facilitate acceleration for both ex vivo and in vivo CDTI, improving reconstruction accuracy compared to employing either constraint alone. Significance: Compared to previous methods for accelerating CDTI, the proposed method has the potential to reach higher acceleration while preserving myofiber architecture features, which may allow more spatial coverage, higher spatial resolution, and shorter temporal footprint in the future.</P>
Lian, Sen,Park, Jung Sun,Xia, Yong,Nguyen, Thi Thinh,Joo, Young Eun,Kim, Kyung Keun,Kim, Hark Kyun,Jung, Young Do MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.10
<P>Emerging evidence supports a fundamental role for microRNAs (miRNA) in regulating cancer metastasis. Recently, <I>microRNA-375</I> (<I>miR-375</I>) was reported to be downregulated in many types of cancers, including gastric cancer. Increase in the expression of Recepteur d’Origine Nantais (RON), a receptor tyrosine kinase, has been reported in tumors. However, the function of <I>miR-375</I> and RON expression in gastric cancer metastasis has not been sufficiently studied. In silico analysis identified <I>miR-375</I> binding sites in the 3′-untranslated regions (3′-UTR) of the RON-encoding gene. Expression of <I>miR-375</I> resulted in reduced activity of a luciferase reporter containing the 3′-UTR fragments of RON-encoding mRNA, confirming that <I>miR-375</I> directly targets the 3′-UTR of RON mRNA. Moreover, we found that overexpression of <I>miR-375</I> inhibited mRNA and protein expression of RON, which was accompanied by the suppression of cell proliferation, migration, and invasion in gastric cancer AGS and MKN-28 cells. Ectopic <I>miR-375</I> expression also induced G1 cell cycle arrest through a decrease in the expression of cyclin D1, cyclin D3, and in the phosphorylation of retinoblastoma (Rb). Knockdown of RON by RNAi, similar to <I>miR-375</I> overexpression, suppressed tumorigenic properties and induced G1 arrest through a decrease in the expression of cyclin D1, cyclin D3, and in the phosphorylation of Rb. Thus, our study provides evidence that <I>miR-375</I> acts as a suppressor of metastasis in gastric cancer by targeting RON, and might represent a new potential therapeutic target for gastric cancer.</P>