http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Scaria, Puthupparampil V. (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Development of a bivalent conjugate vaccine candidate against malaria transmission and typhoid fever
An, So Jung,Scaria, Puthupparampil V.,Chen, Beth,Barnafo, Emma,Muratova, Olga,Anderson, Charles,Lambert, Lynn,Chae, Myung Hwa,Yang, Jae Seung,Duffy, Patrick E. Elsevier 2018 Vaccine Vol.36 No.21
<P><B>Abstract</B></P> <P>Immune responses to poorly immunogenic antigens, such as polysaccharides, can be enhanced by conjugation to carriers. Our previous studies indicate that conjugation to Vi polysaccharide of <I>Salmonella</I> Typhi may also enhance immunogenicity of some protein carriers. We therefore explored the possibility of generating a bivalent vaccine against <I>Plasmodium falciparum</I> malaria and typhoid fever, which are co-endemic in many parts of the world, by conjugating Vi polysaccharide, an approved antigen in typhoid vaccine, to Pfs25, a malaria transmission blocking vaccine antigen in clinical trials. Vi-Pfs25 conjugates induced strong immune responses against both Vi and Pfs25 in mice, whereas the unconjugated antigens are poorly immunogenic. Functional assays of immune sera revealed potent transmission blocking activity mediated by anti-Pfs25 antibody and serum bactericidal activity due to anti-Vi antibody. Pfs25 conjugation to Vi modified the IgG isotype distribution of antisera, inducing a Th2 polarized immune response against Vi antigen. This conjugate may be further developed as a bivalent vaccine to concurrently target malaria and typhoid fever.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
