http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Saurabh Jyoti Sarma (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Sumit Sharma,Shikha Singh,Saurabh Jyoti Sarma 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
A new Aspergillus strain BU20S was isolated and identified by sequence analysis of ribosomal internaltranscribed spacer (ITS) regions. Unknown metabolite produced by the strain was identified by elucidationof molecular structure using a combination of 13C and 1H NMR, MS, FTIR, XRD, and HPLC analysis. Themetabolite was found to be kojic acid, which has the potential to treat methicillin-resistantStaphylococcus aureus (MRSA) infection, among other industrial applications. It was observed that the isolatedstrain can produce kojic acid from castor oil and product titer can be increased by supplementingthe medium with rice straw-derived depolymerized lignin. The substrate concentrations were optimizedby response surface methodology using Design-Expert software. As high as 6.69 ± 0.24 g/L of kojic acidwas obtained using castor oil (20 g/L) and depolymerized rice straw lignin (3 g/L). This is the first reporton kojic acid production from castor oil.
-
Effectiveness of Inorganic Nitrogen on Kojic Acid Production from Fungi Aspergillus sp. BU20S
Sharma Sumit,Singh Shikha,Sarma Saurabh Jyoti 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.4
Kojic acid is a valuable compound that contributes to various therapeutic and cosmetic applications. Organic nitrogen partially contributes to fermentation and mostly prefers cell growth as well as increases production costs. This study aims to fi nd the eff ect of low-cost inorganic nitrogen in the form of ammonium chloride on kojic acid production from fungal isolate Aspergillus sp. BU20S. A 3.63-times increase in the kojic acid (4.43 ± 0.47 g/L) was found when only the ammonium chloride was supplemented in glucose (10 g/L) medium than other minimal salts. The product formation was 2.52 ± 0.56 g/L in ammonium chloride as compared to 2.02 ± 0.06 g/L yeast extract after 10 days. The carbon/nitrogen ratio (C/N) was found optimal as 15 (molecular C/N: 23.58) which gives a high titer of 5.17 ± 0.84 g/L from 10 g/L of glucose. At this optimal molecular nitrogen value, the nitrogen supplement cost can be reduced by 93–99% compared to yeast extract. The antimicrobial potential of kojic acid purifi ed from the fermented broth was also studied against methicillin-resistant Staphylococcus aureus (MRSA). The purifi ed kojic acid showed a ~ 20 mm zone of inhibition at a 2.5 mg dose loaded over 7.4 × 10 9 CFU/ mL of MRSA. This study concludes that only ammonium chloride is a suffi cient inorganic nitrogen source to produce kojic acid and is useful in reducing production costs. The purifi ed kojic acid is also an eff ective antimicrobial agent.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
