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Sarma, Sailendra Nath,Kim, Youn-Jung,Jeon, Hee-Kyung,Ryu, Jae-Chun The Korean Society of Toxicogenomics and Toxicopro 2006 Molecular & cellular toxicology Vol.2 No.4
Volatile organic compounds (VOCs) are a major component of urban air pollution. It is documented that low exposure levels of VOCs induce alterations in immune reactivity resulting in a subsequent higher risk for the development of allergic reactivity and asthma. Despite these facts, there are few reports on the affected primary target and the underlying effective causal mechanisms. So in this study, to better understand the risk of BTX (benzene, toluene and o-xylene) which are the major VOCs and to identify novel biomarkers on immune response to these VOCs exposure in human T lymphocytes, we performed the toxicogenomic study by analyzing of gene expression profiles using 35 k human oligo-microarray. BTX generated specific gene expression patterns in Jurkat cell line. By clustering analysis, we identified some genes as potential markers on immuno-modulating effects of BTX. Four genes of these, HLA-DOA, ITGB2, HMGA2 and 5TAT4 were the most significantly affected by BTX exposure. Thus, this study suggests that these differentially expressed immune genes may play an important role in the pathogenesis on BTX exposure and have significant potential as novel biomarkers of exposure, susceptibility and response to BTC.
ASYMPTOTIC BEHAVIOR OF SOLUTIONS OF MATRIX LYAPUNOV INTEGRO DIFFERENTIAL EQUATIONS
Sarma, Goteti V.R.L.,Hugo, Alfred The Korean Society for Computational and Applied M 2014 Journal of applied mathematics & informatics Vol.32 No.5
The asymptotic behavior of solutions of Lyapunov type matrix Volterra integro differential equation, in which the coefficient matrices are not stable, is studied by the method of reduction.
Sarma, Sailendra Nath,Kim, Youn-Jung,Ryu, Jae-Chun The Korean Society of Toxicogenomics and Toxicopro 2008 Molecular & cellular toxicology Vol.4 No.4
Benzene and ethylbenzene (BE), the volatile organic compounds (VOCs) are common constituents of cleaning and degreasing agents, paints, pesticides, personal care products, gasoline and solvents. VOCs are evaporated at room temperature and most of them exhibit acute and chronic toxicity to human. Chronic exposure of benzene is responsible for myeloid leukemia and also ethylbenzene is also recognized as a possible carcinogen. To evaluate the BE effect on human, whole human genome 35 K oligonucleotide microarray were screened for the identification of the differential expression profiling. We identified 280 up-regulated and 201 down-regulated genes changed by more than 1.5 fold by BE exposure. Functional analysis was carried out by using DAVID bioinformatics software. Clustering of these differentially expressed genes were associated with immune response, cytokine-cytokine receptor interaction, toll-like signaling pathway, small cell lung cancer, immune response, apoptosis, p53 signaling pathway and MAPKKK cascade possibly constituting alternative or subordinate pathways of hematotoxicity and immune toxicity. Gene ontology analysis methods including biological process, cellular components, molecular function and KEGG pathway thus provide a fundamental basis of the molecular pathways through BEs exposure in human lymphoma cells. This may provides a valuable information to do further analysis to explore the mechanism of BE induced hematotoxicity.
Sarma Nittala S.,Baliarsingh Sanjiba Kumar,Lotliker Aneesh Anandrao,Pandi Sudarsana Rao,Samanta Alakes,Srichandan Suchismita 한국해양과학기술원 2023 Ocean science journal Vol.58 No.1
Green Noctiluca scintillans (NSG) is a mixotrophic dinofagellate that frequently forms intense blooms in the north Indian Ocean, especially in the northeastern Arabian Sea during winter. This study investigates the conducive conditions and drivers associated with NSG blooms and proposes signifcant models for estimating NSG based on in situ (time-series) study during the bloom cycles. Two critical factors with regard to the blooms, i.e., phytoplankton abundance and sea surface temperature (SST), were examined. The frst phase of heterotrophy dominance was when moderate blooms up to~ 2.26× 104 cells 1–1 occurred and, when NSG cells per unit chlorophyll-a (chl-a) increased, SST decreased up to~24.5 ºC. The bloom intensity was proportional to the feed (diatoms/phytoplankton) availability and the degree of cooling (by the winter convection, i.e., nutrient enrichment). In the second phase of autotrophy dominance, intense blooms up to 1.9× 105 cells l −1 occurred and NSG cells per unit chl-a fell, when the SST increased. During this period, bloom intensity was proportional to the degree of warming, i.e., nutrient and physiological stress. Phytoplankton are related to NSG by a single linear model through this SST cycle and is likely the NSG’s essential biotic precursor. Attention is then focused on developing a remote sensing refectance (Rrs) model for efcient synoptic monitoring of NSG using ocean color satellites. The Rrs band product ratio, a new metric, in combination with SST, notably modelled NSG abundance, which may be of potential routine application.
Sarma, Usha,Mahanta, Jagadish,Borkakoty, Biswajyoti,Sarmah, Bidula Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Infection of the uterine cervix by human papilloma viruses (HPV) may be associated with cervical pre-cancer and invasive cervical carcinoma if left untreated. With advance in molecular techniques, it has become easier to detect the resence of HPV DNA long before the appearance of any lesion. This study concerned cervical scrape samples of 310 married non-pregnant women attending a gynecology outpatient department for both Pap and PCR testing to detect HPV DNA. Nested PCR using primers for L1 consensus gene with My9/My11 and GP6+/GP5+followed by multiplex PCR were carried out to detect HPV 16 and HPV18. Result: HPV prevalence was 11.9% out of which 3.67% cases of negative for intra-epithelial lesion or malignancy (NILM) and in 71.1% (27/38) of atypical cervical smears were HPV positive. There was increasing trend of high-risk-HPV positivity (HR HPV 16 and 18), from 20% in benign cytology (NILM) to 42.9 % in LSIL, 71.41% in HSIL and 100% in SCC. There was highly significant association of HPV infection with cervical lesion ($x^2=144.0$, p<0.01) and also with type specific HPV prevalence ($x^2=7.761^*$, p<0.05).
Upasana Sarma,Viney Kumar Govila,Akanksha Yadav 한국식품연구원 2020 Journal of Ethnic Foods Vol.7 No.-
Assam lies nestled in the far north-east corner of the Indian subcontinent. A country blessed with ample natural resources, the state of Assam also has a plethora of options in terms of choosing their core food sources. Banana or kol, as named in Assamese, has hundreds of varieties available in many parts of the world. They grow particularly well in tropical countries. It is found abundantly in the state of Assam and people have been making judicious use of the fruit and its plant parts in their cuisine since time immemorial. But nevertheless, a detailed review on its uses and importance and rising popularity in ethnic delicacies has not yet been documented well. This paper attempts to bring together the popular banana-based recipes of Assam state and its use in everyday religious ceremonies by the people of this community. It has age-old recipes used commonly in Assamese households and descriptive analysis of their microbial and biochemical diversity. It aims to bring to the fore the rising popularity of these ethnic dishes amongst modern population and is an attempt to revive these dishes and bring them into the mainstream Indian ethnic cuisine. As more and more people become aware of ethnic cuisine, it increases a global connectivity based on exchange of such information from lesser-known sources. The importance and significance of documenting these lesser-known recipes of Indian Assamese cuisine is an attempt to keep it relevant and take it to a broader audience who are appreciative of such oriental dishes. It is also high time a policy framework is worked upon by respective government of state and the centre for the true recognition and sustainability of such ethnic cuisine.
Migrancy and Memory in Siddhartha Deb’s Novel The Point of Return
Arindam SARMA 이화여자대학교 이화인문과학원 2016 탈경계인문학 Vol.9 No.1
Siddhartha Deb’s novel The Point of Return (2002) is a nuanced study of the fractured relationship between an indigenous tribal people and Bengali migrants in the undivided state of Assam, and the exilic condition of these migrants in the Northeast of India (especially in Assam and Meghalaya). It also shows the painful process of cartographic reconfigurations of state boundaries along ethnic lines, and the resultant violence, uprootedness, alienation, and continued memory of loss. The paper seeks to investigate how the writer traces the lives of the first generation migrants who came to the new land in search of a better life but were condemned to live precarious lives in their adopted homeland. The novel is also about the post-partition generation who inherited the memory of their parents and grandparents and had to negotiate their own sense of belonging and identity in the face of ethnic assertion by indigenous people in the eastern borderland region. The legacy of this conflict lives on in the Northeast as the post-partition generation continues to grapple with issues like displacement, cultural confrontation, and homelessness. At the same time, we have examined how Deb utilizes the mode of memory to tell his story of migrancy and the trauma of loss and dislocation. The act of remembering, the urge to recall and revisit the historical loss, fracture, and trauma, are insistent in the text even as it grapples with issues like home, identity, citizenship, and belonging in the postcolonial nation-state.