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Alqahtani, Masood,Grieu, Fabienne,Carrello, Amerigo,Amanuel, Benhur,Mashour, Miral,Alattas, Rabab,Al-Saleh, Khalid,Alsheikh, Abdulmalik,Alqahtani, Sarah,Iacopetta, Barry Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: Lynch Syndrome (LS) is a familial cancer condition caused by germline mutations in DNA mismatch repair genes. Individuals with LS have a greatly increased risk of developing colorectal cancer (CRC) and it is therefore important to identify mutation carriers so they can undergo regular surveillance. Tumor DNA from LS patients characteristically shows microsatellite instability (MSI). Our aim here was to screen young CRC patients for MSI as a first step in the identification of unrecognized cases of LS in the Saudi population. Materials and Methods: Archival tumor tissue was obtained from 284 CRC patients treated at 4 institutes in Dammam and Riyadh between 2006 and 2015 and aged less than 60 years at diagnosis. MSI screening was performed using the BAT-26 microsatellite marker and positive cases confirmed using the pentaplex MSI analysis system. Positive cases were screened for BRAF mutations to exclude sporadic CRC and were evaluated for loss of expression of 4 DNA mismatch repair proteins using immunohistochemistry. Results: MSI was found in 33/284 (11.6%) cases, of which only one showed a BRAF mutation. Saudi MSI cases showed similar instability in the BAT-26 and BAT-25 markers to Australian MSI cases, but significantly lower frequencies of instability in 3 other microsatellite markers. Conclusions: MSI screening of young Saudi CRC patients reveals that approximately 1 in 9 are candidates for LS. Patients with MSI are strongly recommended to undergo genetic counselling and germline mutation testing for LS. Other affected family members can then be identified and offered regular surveillance for early detection of LS-associated cancers.
SYN Flood DoS Detection System Using Time Dependent Finite Automata
Noura AlDossary,Sarah AlQahtani,Reem Alzaher,Atta-ur-Rahman International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.6
Network intrusion refers to any unauthorized penetration or activity on a computer network. This upsets the confidentiality, integrity, and availability of the network system. One of the major threats to any system's availability is a Denial-of-Service (DoS) attack, which is intended to deny a legitimate user access to resources. Therefore, due to the complexity of DoS attacks, it is increasingly important to abstract and describe these attacks in a way that will be effectively detected. The automaton theory is used in this paper to implement a SYN Flood detection system based on Time-Dependent Finite Automata (TDFA).
Mahmoud, Ayman M.,Alqahtani, Sultan,Othman, Sarah I.,Germoush, Mousa O.,Hussein, Omnia E.,Al-Basher, Gadh,Khim, Jong Seong,Al-Qaraawi, Maha A.,Al-Harbi, Hanan M.,Fadel, Abdulmannan,Allam, Ahmed A. Hindawi 2017 Oxidative medicine and cellular longevity Vol.2017 No.-
<P>Hyperammonemia is a serious complication of liver disease and may lead to encephalopathy and death. This study investigated the effects of <I>Commiphora molmol</I> resin on oxidative stress, inflammation, and hematological alterations in ammonium chloride- (NH<SUB>4</SUB>Cl-) induced hyperammonemic rats, with an emphasis on the glutamate-NO-cGMP and Nrf2/ARE/HO-1 signaling pathways. Rats received NH<SUB>4</SUB>Cl and <I>C. molmol</I> for 8 weeks. NH<SUB>4</SUB>Cl-induced rats showed significant increase in blood ammonia, liver function markers, and tumor necrosis factor-alpha (TNF-<I>α</I>). Concurrent supplementation of <I>C. molmol</I> significantly decreased circulating ammonia, liver function markers, and TNF-<I>α</I> in hyperammonemic rats. <I>C. molmol</I> suppressed lipid peroxidation and nitric oxide and enhanced the antioxidant defenses in the liver, kidney, and cerebrum of hyperammonemic rats. <I>C. molmol</I> significantly upregulated Nrf2 and HO-1 and decreased glutamine and nitric oxide synthase, soluble guanylate cyclase, and Na<SUP>+</SUP>/K<SUP>+</SUP>-ATPase expression in the cerebrum of NH<SUB>4</SUB>Cl-induced hyperammonemic rats. Hyperammonemia was also associated with hematological and coagulation system alterations. These alterations were reversed by <I>C. molmol</I>. Our findings demonstrated that <I>C. molmol</I> attenuates ammonia-induced liver injury, oxidative stress, inflammation, and hematological alterations. This study points to the modulatory effect of <I>C. molmol</I> on glutamate-NO-cGMP and Nrf2/ARE/HO-1 pathways in hyperammonemia. Therefore, <I>C. molmol</I> might be a promising protective agent against hyperammonemia.</P>
Detection and Real-Time Monitoring of LDL-Cholesterol by Redox-Free Impedimetric Biosensors
Abdulaziz K. Assaifan,Fatimah A. Alqahtani,Sarah Alnamlah,Rasha Almutairi,Hend I. Alkhammash 한국바이오칩학회 2022 BioChip Journal Vol.16 No.2
In this work, non-faradaic impedimetric biosensor was developed for the direct detection of low-density lipoprotein (LDLcholesterol). Unlike other electrochemical techniques, non-faradaic electrochemical impedance spectroscopy (EIS) does not require the use of redox probes which denatures targeted biomarkers. Furthermore, no reference electrode is required for detection which is commercially viable. The biosensor reported here consists of LDL-antibodies attached to interdigitated gold electrodes via standard chemical functionalization. The biosensor demonstrated a sensitivity and limit of detection (LoD) of 70 nF/log(ng/mL) and 120 pg/mL, respectively, where the LoD is well below the recommended LDL level in blood. The biosensor also demonstrated good selectivity toward LDL. Thereafter we utilized, for the first time, the non-faradaic impedimetric biosensor for the continuous monitoring of LDL in phosphate buffer saline (PBS). The biosensor showed rapid responses to LDL injections. Such an approach is essential for the development of low-cost and scalable wearable biosensors for the direct real-time monitoring of chronic diseases and hence allows early medical interventions in cases where sudden increases in LDL or other biomarkers are deadly.
A Simulation Modeling for the Effect of Resource Consumption Attack over Mobile Ad Hoc Network
Raed Alsaqour,Maha Abdelhaq,Njoud Alghamdi,Maram Alneami,Tahani Alrsheedi,Salma Aldghbasi,Rahaf Almalki,Sarah Alqahtani International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.9
Mobile Ad-hoc Network (MANET) is an infrastructure-less network that can configure itself without any centralized management. The topology of MANET changes dynamically which makes it open for new nodes to join it easily. The openness area of MANET makes it very vulnerable to different types of attacks. One of the most dangerous attacks is the Resource Consumption Attack (RCA). In this type of attack, the attacker consumes the normal node energy by flooding it with bogus packets. Routing in MANET is susceptible to RCA and this is a crucial issue that deserves to be studied and solved. Therefore, the main objective of this paper is to study the impact of RCA on two routing protocols namely, Ad hoc On-Demand Distance Vector (AODV) and Dynamic Source Routing (DSR); as a try to find the most resistant routing protocol to such attack. The contribution of this paper is a new RCA model (RCAM) which applies RCA on the two chosen routing protocols using the NS-2 simulator.