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        Study of effective parameters for the polarization characterization of PEMFCs sensitivity analysis and numerical simulation

        Sara Barati,Mohsen Mehdipour Ghazi,Behnam Khoshandam 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.1

        A three-dimensional model of a HT-PEMFC was simulated using Comsol Multiphysics software. Sensitivity was analyzed by using the three-level Box-Behnken experimental design. The effect of independent variables on the fuel cell performance including air and hydrogen velocity, temperature and amount of phosphoric acid doping level (PAdop) on the membrane was investigated. The results showed that the PAdop is the most important variable. The simulation results showed that with the increasing of the PAdop from 2 to 16, the current density (at a voltage of 0.4 V) increased from 0.3 to 0.9A/cm2, which confirms the importance of the PAdop factor on the fuel cell performance.

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        Post-dural puncture headache prevention and treatment with aminophylline or theophylline: a systematic review and meta-analysis

        Barati-Boldaji Reza,Shojaei-Zarghani Sara,Mehrabi Manoosh,Amini Afshin,Safarpour Ali Reza 대한마취통증의학회 2023 Anesthesia and pain medicine Vol.18 No.2

        Background: Post-dural puncture headache (PDPH) is one of the most common complications in patients undergoing spinal anesthesia. The present systematic review and meta-analysis aimed to assess the therapeutic and prophylactic effects of aminophylline and theophylline on PDPH.Methods: Relevant studies were identified by searching the following electronic databases, without language restriction, until June 2020: Scopus, EMBASE, MEDLINE, Google Scholar, Web of Science, Cochrane Library-CENTRAL, and CINAHL Complete. Random effects models were used to calculate the standardized mean difference (SMD) and risk ratios (RRs) with 95% confidence intervals (95% CI) to assess the therapeutic and prophylactic effects of aminophylline and theophylline on PDPH, respectively. The Cochrane tool was used for the quality assessment of the included studies. The certainty of the evidence was rated using the Grading of Recommendations Assessment, Development, and Evaluation method.Results: Of the 1,349 initial records, 15 met our eligibility criteria (6 studies on therapeutic and 9 on prophylactic effects). A significant reduction in the pain score was observed following aminophylline/theophylline treatment (SMD = –1.67; 95% CI, –2.28 to –1.05; P < 0.001, I2 = 84.7%; P < 0.001). Subgroup analysis revealed that the therapeutic effect was significantly higher when these agents were compared to placebo than when conventional therapies were used. The risk of PDPH after aminophylline administration was not significantly reduced (RR = 0.74; 95% CI, 0.42 to 1.31; P = 0.290).Conclusions: Theophylline and aminophylline have therapeutic, but not prophylactic, effects on PDPH.

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