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Preclinical evaluation of Kali Haldi (Curcuma caesia): a promising herb to treat type-2 diabetes
Poulami Majumder,Pallab Kanti Haldar,Suchandra Mazumder,Mainak Chakraborty,Srila Ghosh Chowdhury,Samit Karmakar 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.2
The methanol extract of Curcuma caesia (MECC) rhizome showed antidiabetic activity by lowering blood glucose in in vivo studies and controlled intestinal absorption of monosaccharides by inhibiting alpha amylase and alpha glucosidase. It also enhanced the glucose uptake in yeast cells, proving proper glucose utilization. The IC50 values of MECC were found to be 442.92 ± 10.05 μg/ml and 95.40 ± 9.74 μg/ml in alpha amylase and alpha glucosidase inhibition respectively. The extract has effective antioxidant activities, by successfully scavenging free radicals like superoxide and hydroxyl ions. The histopathological studies of pancreas showed gradual healing after treatment.