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        Determining Unemployment Factors Among Job Seeking Youth in the East Coast of Peninsular Malaysia

        SHAKUR, Elia Syarafina Abdul,SA'AT, Nor Hayati,AZIZ, Nazli,ABDULLAH, Siti Salina,RASID, Nor Hafzan Abd Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.12

        This study examines factors of unemployment and career path challenges commonly faced by youth in the East Coast of Peninsular Malaysia. The study employed a quantitative approach which involved a total of 1,083 youths in Kelantan, Pahang and Terengganu selected at random. Descriptive and multiple regression analysis (OLS) methods were used to analyze demographic distribution of youth in determining factors influencing unemployment among them. The results reveal that the majority of youth respondents in the East Coast states of Malaysia are still unemployed and actively seeking employment. Demographic profiles are based on the survey results, youths seeking employment with 36 per cent distribution in Kelantan, 34 per cent in Pahang, and 30 per cent in Terengganu. Majority of the respondents were youths aged 20 to 24 years with a 40.9 percent percentage. The findings show that there are differences in factors affecting youth unemployment in the three states of East Coast, Malaysia. For Kelantan (age, experience, work mobility, marital status), Pahang (experience, marital status) and Terengganu (experience, gender, marital status, training). This study suggests that youths should be wise in preparing for their career by choosing the right career as well as doing side jobs to gain experience before they pursue for a real job.

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        Long-term Safety and Efficacy of Esketamine Nasal Spray Plus an Oral Antidepressant in Patients with Treatment-resistant Depression- an Asian Sub-group Analysis from the SUSTAIN-2 Study

        Hong Jin Jeon,Po-Chung Ju,Ahmad Hatim Sulaiman,Salina Abdul Aziz,Jong-Woo Paik,Wilson Tan,Daisy Bai,Cheng-Ta Li 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.1

        Objective: To evaluate the long-term safety and efficacy of intranasal esketamine in patients with treatment-resistant depression from the Asian subgroup of the SUSTAIN-2 study. Methods: SUSTAIN-2 was a phase 3, open-label, single-arm, multicenter study comprising a 4-week screening, 4-week induction, 48-week optimization/maintenance, and 4-week follow-up (upon esketamine discontinuation) phase. Patients with treatment-resistant depression received esketamine plus an oral antidepressant during the treatment period. Results: The incidence of ≥ 1 serious treatment-emergent adverse event (TEAE) among the 78 subjects from the Asian subgroup (Taiwan: 33, Korea: 26, Malaysia: 19) was 11.5% (n = 9); with no fatal TEAE. 13 Asian patients (16.7%) discontinued esketamine due to TEAEs. The most common TEAEs were dizziness (37.2%), nausea (29.5%), dissociation (28.2%), and headache (21.8%). Most TEAEs were mild to moderate in severity, transient and resolved on the same day. Upon discontinuation of esketamine, no trend in withdrawal symptoms was observed to associate long-term use of esketamine with withdrawal syndrome. There were no reports of drug seeking, abuse, or overdose. Improvements in symptoms, functioning and quality of life, occurred during in the induction phase and were generally maintained through the optimization/maintenance phases of the study. Conclusion: The safety and efficacy of esketamine in the Asian subgroup was generally consistent with the total SUSTAIN-2 population. There was no new safety signal and no indication of a high potential for abuse with the long-term (up to one year) use of esketamine in the Asian subgroup. Most of the benefits of esketamine occurred early during the induction phase.

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