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RISS 인기검색어
- 검색키워드
- 저자 : Saeed Tavassoli (검색결과 2 건)
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An analytical determining the internal ring gear rim stiffness for practical purpose
Saeed Tavassoli,Mehrdad Poursina,Davood Poursina 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.10
Internal ring gears have a wide application in planetary gearboxes and transmission systems. The mesh stiffness of planetary gearboxes is an essential parameter for dynamic and vibration analysis. No direct practical method for calculating the stiffness of the internal ring gear rim has been investigated yet to the authors' knowledge. For the first time in this research, a practical method is presented to determine the stiffness of the internal ring gear rim with an appropriate accuracy based on strain energy. To accomplish this goal, every part of the internal ring gear rim, which is between two consecutive pins or bolts, is modeled as a curved beam. The deflection of the curved beam is determined according to Castigliano's theorem. Then, the stiffness of the internal ring gear rim is obtained through this deflection. Fourier’s series of deflections are calculated to make analytical results more comfortable to use. Finally, the analytical results are validated by FEM using ABAQUS software.
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Shiri, Sadaf,Alizadeh, Ali Mohammad,Baradaran, Behzad,Farhanghi, Baharak,Shanehbandi, Dariush,Khodayari, Saeed,Khodayari, Hamid,Tavassoli, Abbas Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Curcumin, a lipid-soluble compound extracted from the plant Curcuma Longa, has been found to exert immunomodulatory effects via macrophages. However, most studies focus on the low bioavailability issue of curcumin by nano and microparticles, and thus the role of macrophages in the anticancer mechanism of curcumin has received little attention so far. We have previously shown the potential biocompatibility, biodegradability and anti-cancer effects of dendrosomal curcumin (DNC). In this study, twenty-seven BALB/c mice were equally divided into control as well as 40 and 80 mg/kg groups of DNC to investigate the involvement of macrophages in the antitumor effects of curcumin in a typical animal model of metastatic breast cancer. At the end of intervention, the tumor volume and weight were significantly reduced in DNC groups compared to control (P<0.05). Histopathological data showed the presence of macrophages in tumor and spleen tissues. Real-time PCR results showed that DNC increased the expression of STAT4 and IL-12 genes in tumor and spleen tissues in comparison with control (P<0.05), referring to the high levels of M1 macrophages. Furthermore treatment with DNC decreased STAT3, IL-10 and arginase I gene expression (P<0.05), indicating low levels of M2 macrophage. The results confirm the role of macrophages in the protective effects of dendrosomal curcumin against metastatic breast cancer in mice.
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