http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Tae-Sung,Park, Jung-Eun,Shukla, Anil,Choi, Sunho,Murugan, Ravichandran N.,Lee, Jin H.,Ahn, Mija,Rhee, Kunsoo,Bang, Jeong K.,Kim, Bo Y.,Loncarek, Jadranka,Erikson, Raymond L.,Lee, Kyung S. National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.50
<P>Centrosomes play an important role in various cellular processes, including spindle formation and chromosome segregation. They are composed of two orthogonally arranged centrioles, whose duplication occurs only once per cell cycle. Accurate control of centriole numbers is essential for the maintenance of genomic integrity. Although it is well appreciated that polo-like kinase 4 (Plk4) plays a central role in centriole biogenesis, how it is recruited to centrosomes and whether this step is necessary for centriole biogenesis remain largely elusive. Here we showed that Plk4 localizes to distinct subcentrosomal regions in a temporally and spatially regulated manner, and that Cep192 and Cep152 serve as two distinct scaffolds that recruit Plk4 to centrosomes in a hierarchical order. Interestingly, Cep192 and Cep152 competitively interacted with the cryptic polo box of Plk4 through their homologous N-terminal sequences containing acidic-alpha-helix and N/Q-rich motifs. Consistent with these observations, the expression of either one of these N-terminal fragments was sufficient to delocalize Plk4 from centrosomes. Furthermore, loss of the Cep192- or Cep152-dependent interaction with Plk4 resulted in impaired centriole duplication that led to delayed cell proliferation. Thus, the spatiotemporal regulation of Plk4 localization by two hierarchical scaffolds, Cep192 and Cep152, is critical for centriole biogenesis.</P>
Dielectric and Optical Study of Polymer Nematic Liquid Crystal Composite
S. MANOHAR,V. S. CHANDEL,S. N. SHUKLA,J. P. SHUKLA,R. MANOHAR 한국전기전자재료학회 2013 Transactions on Electrical and Electronic Material Vol.14 No.3
The dielectric anisotropy and dispersion of the real and imaginary part of the permittivity of commercially important nematic mixture E-24 and its polymer composite were investigated in the frequency range from 1 kHz to 10 MHz, and temperature range 14℃ to 55℃. The percentage optical transmittance and density have also been measured for both the systems. The results have been explained by assuming molecular rotation about the long molecular axis, under a hindering nematic potential. The dielectric anisotropy Δε is positive, and the mean dielectric permittivity falls with rising temperature. Δε is also used to determine the order parameter with varying temperature.
Rajeevan, N E,Kumar, Ravi,Shukla, D K,Thakur, P,Brookes, N B,Chae, K H,Choi, W K,Gautam, S,Arora, S K,Shvets, I V,Pradyumnan, P P IOP Pub 2009 Journal of physics, an Institute of Physics journa Vol.21 No.40
<P>We report the near-edge x-ray absorption spectroscopy (NEXAFS) at the Co/Mn L-3,L-2 edge and oxygen K edge of the well-characterized Bi-substituted Co2MnO4 multiferroic samples. The evolution of peak features in NEXAFS spectra of the Co/Mn L-3,L-2 edge and O K edge show the Bi-induced redistribution of magnetic cations (Co/Mn). The variation in valence states of Co and Mn in all the substituted compositions is consistent with the observed ferrimagnetic behaviour of the samples. Magnetization data show the decrease in molecular field complementing the ferrimagnetism. The role of Bi in the enhancement of magnetic interactions as well as the appearance of ferroelectricity in BixCo2-xMnO4 (0 <= x <= 0.3) is discussed.</P>
Dielectric and Optical Study of Polymer Nematic Liquid Crystal Composite
Manohar, S.,Shukla, S.N.,Chandel, V.S.,Shukla, J.P.,Manohar, R. The Korean Institute of Electrical and Electronic 2013 Transactions on Electrical and Electronic Material Vol.14 No.3
The dielectric anisotropy and dispersion of the real and imaginary part of the permittivity of commercially important nematic mixture E-24 and its polymer composite were investigated in the frequency range from 1 kHz to 10 MHz, and temperature range $14^{\circ}C$ to $55^{\circ}C$. The percentage optical transmittance and density have also been measured for both the systems. The results have been explained by assuming molecular rotation about the long molecular axis, under a hindering nematic potential. The dielectric anisotropy ${\Delta}{\varepsilon}$ is positive, and the mean dielectric permittivity falls with rising temperature. ${\Delta}{\varepsilon}$ is also used to determine the order parameter with varying temperature.
Effect of proton irradiation on electrical properties of a-As<sub>2</sub>S<sub>3</sub>
Gautam, S.,Thakur, A.,Shukla, D.K.,Shin, H.J.,Chae, K.H.,Singh, K.P.,Goyal, N. North-Holland 2011 Journal of non-crystalline solids Vol.357 No.11
This paper reports the effect of proton irradiation on the electrical properties of a-As<SUB>2</SUB>S<SUB>3</SUB> in the temperature range of 323-418K and frequency range 0.1-100kHz. The variation of transport property is studied with proton irradiation dose (1x10<SUP>13</SUP>ions/cm<SUP>2</SUP> and 1x10<SUP>15</SUP>ions/cm<SUP>2</SUP>). It has been observed that proton irradiation changes the dc conductivity (σ<SUB>dc</SUB>), dc activation energy (ΔE<SUB>dc</SUB>) and ac conductivity (σ<SUB>ac</SUB>(ω)). The σ<SUB>dc</SUB> and σ<SUB>ac</SUB>(ω) increases with dose of proton irradiation. The value of frequency exponent (s) decreases with the temperature and irradiation dose. These results are explained in terms of change in density of defect states in these glasses.
Shukla Vikram,Gera Bhuvaneshwar,Ganju Sunil,Varma Salil,Maheshwari N.K.,Guchhait P.K.,Sengupta S. 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.11
Hydrogen mitigation using Passive Autocatalytic Recombiners (PARs) has been widely accepted methodology inside reactor containment of accident struck Nuclear Power Plants. They reduce hydrogen concentration inside reactor containment by recombining it with oxygen from containment air on catalyst surfaces at ambient temperatures. Exothermic heat of reaction drives the product steam upwards, establishing natural convection around PAR, thus invoking homogenisation inside containment. CFD models resolving individual catalyst plate channels of PAR provide good insight about temperature and hydrogen recombination. But very thin catalyst plates compared to large dimensions of the enclosures involved result in intensive calculations. Hence, empirical correlations specific to PARs being modelled are often used in integral containment studies. In this work, an experimentally validated CFD model of PAR has been employed for developing an empirical correlation for Indian PAR. For this purpose, detailed parametric study involving different gas mixture variables at PAR inlet has been performed. For each case, respective values of gas mixture variables at recombiner outlet have been tabulated. The obtained data matrix has then been processed using regression analysis to obtain a set of correlations between inlet and outlet variables. The empirical correlation thus developed, can be easily plugged into commercially available CFD software.
A. Gourishankar,K.N. Ganesh,S. Shukla,R. Pasricha,M. Sastry 한국물리학회 2005 Current Applied Physics Vol.5 No.2
Organisation of nanoparticles on structurally well-dened templates is a rst step towards creating nanomachines. In this respect,nucleic acids are ideal structural templates and a variety of secondary structures realizable from DNA/RNAe.g., duplexes, hair-pins, triplexes, cruciforms, tetraplexes can be exploited to engineer nanoparticle organization at will. We have used oligonucleotidesand their analogues such as phosphorothioates and peptide nucleic acids to electrostatically encapsulate cationic-capped gold na-noparticles. This article describes synthesis and characterization of DNA/PNA-gold nanoparticle composites using TEMandUV-Tm techniques. These types of assemblies may have potential for creating nanowires and lithographic circuits.. 2004 Elsevier B.V. All rights reserved.
Patel, Kinjal R.,Vajaria, Bhairavi N.,Begum, Rasheedunnisa,Shah, Franky D.,Patel, Jayendra B.,Shukla, Shilin N.,Patel, Prabhudas S. Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Background: p53 gene variants i.e. 16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies. Therefore, the present study evaluated the role of these p53 polymorphisms in oral cancer susceptibility in a population from Gujarat, West India. Method: Genotype frequencies at the three p53 loci in 110 controls and 79 oral cancer cases were determined by the PCR-RFLP method. Results: Heterozygous individuals at exon 4 showed protection from developing oral cancer. Homozygous wild and heterozygous individuals at intron 3 and those heterozygous at exon 4 in combination appeared to be at lowered risk. Furthermore, carriers of the 16 bp duplication allele at intron 3, proline allele at exon 4 and G allele at intron 6 were protected from oral cancer development. Conclusion: p53 polymorphisms, especially Arg72Pro in exon 4 could significantly modify the risk of oral cancer development in Gujarat, West Indian population.
Patel, Jayendra B.,Patel, Kinjal D.,Patel, Shruti R.,Shah, Franky D.,Shukla, Shilin N.,Patel, Prabhudas S. Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Regardless of advances in treatment modalities with the invention of newer therapies, breast cancer remains a major health problem with respect to its diagnosis, treatment and management. This female malignancy with its tremendous heterogeneous nature is linked to high incidence and mortality rates, especially in developing region of the world. It is the malignancy composed of distinct biological subtypes with diverse clinical, pathological, molecular and genetic features as well as different therapeutic responsiveness and outcomes. This inconsistency can be partially overcome by finding novel molecular markers with biological significance. In recent years, newer technologies help us to indentify distinct biomarkers and increase our understanding of the molecular basis of breast cancer. However, certain issues need to be resolved that limit the application of gene expression profiling to current clinical practice. Despite the complex nature of gene expression patterns of cDNAs in microarrays, there are some innovative regulatory molecules and functional pathways that allow us to predict breast cancer behavior in the clinic and provide new targets for breast cancer treatment. This review describes the landscape of different molecular markers with particular spotlight on vitamin D signaling pathway and apoptotic specific protein of p53 (ASPP) family members in breast cancer.
Clinico-pathological Profile of Lung Cancer at AIIMS: A Changing Paradigm in India
Malik, Prabhat Singh,Sharma, Mehar Chand,Mohanti, Bidhu Kalyan,Shukla, N.K.,Deo, S.V.S.,Mohan, Anant,Kumar, Guresh,Raina, Vinod Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: Lung cancer is one of the commonest and most lethal cancers throughout the world. The epidemiological and pathological profile varies among different ethnicities and geographical regions. At present adenocarcinoma is the commonest histological subtype of non-small cell lung cancer (NSCLC) in most of the Western and Asian countries. However, in India squamous cell carcinoma has been reported as the commonest histological type in most of the series. The aim of the study was to analyze the current clinico-pathological profile and survival of lung cancer at our centre. Materials and Methods: We analyzed 434 pathologically confirmed lung cancer cases registered at our centre over a period of three years. They were evaluated for their clinical and pathological profiles, treatment received and outcome. The available histology slides were reviewed by an independent reviewer. Results: Median age was 55 years with a male:female ratio of 4.6:1. Some 68% of patients were smokers. There were 85.3% NSCLC and 14.7% SCLC cases. Among NSCLCs, adenocarcinoma was the commonest histological subtype after the pathology review. Among NSCLC, 56.8% cases were of stage IV while among SCLC 71.8% cases had extensive stage disease. Some 29% of patients did not receive any anticancer treatment. The median overall and progression free survivals of the patients who received treatment were 12.8 and 7.8 months for NSCLC and 9.1 and 6.8 months for SCLC. Conclusions: This analysis suggests that adenocarcinoma may now be the commonest histological subtype also in India, provided a careful pathological review is done. Most of the patients present at advanced stage and outcome remains poor.